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The gut microbiota plays a vital role in maintaining the physiological function of host health and the pathogenesis of various diseases. However, its relationship with maternal age-associated decline in oocyte quality remains elusive. Here, we report that establishment of gut microbiota from youn...

2026-05-07 | MTBLS14062 | MetaboLights
TOP2B disturbed the quality of human oocytes with advanced maternal age
Single-cell proteomics analysis of human oocytes from both young and old women
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-01-15 | MSV000093870 | MassIVE
Transcriptomic Profiling of human granulosa cells between women with advanced maternal age with different ovarian reserves
Single-cell transcriptome analyses reveal disturbed decidual microenvironment in women of advanced maternal age
Ovulation suppression protects against chromosomal abnormalities in mouse eggs at advanced maternal age
Prenatal fetal head and placental gene expression in a mouse model of advanced maternal age

Advanced maternal age is a key factor in female infertility, primarily due to declines in ovarian reserve and oocyte quality. However, the metabolic mechanisms underlying reproductive aging are still poorly understood. Here, we show that uridine levels in the plasma and ovaries of aged mice are s...

2026-03-03 | MTBLS13957 | MetaboLights
Increased locomotor activity does not mitigate the effects of advanced maternal age in a mouse model
RICTOR prevents decidualization disorder in women with advanced maternal age via regulating FoxO1 nuclear export
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