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GenomicsChIP-seq of primary human macrophages uninfected or infected with Yersinia enterocolitica strains
Pathogenic bacteria Yersinia enterocolitica injects virulence plasmid-encoded effectors through the type three secretion system into macrophages to modulate gene expression. At this point it is not known whether epigenetic modifications play a role in Yersinia regulation of gene expression. To answe...
ORGANISM(S): Homo sapiens 
2021-11-07 | E-MTAB-10475 | biostudies-arrayexpress
TranscriptomicsRNA-seq of primary human macrophages infected with Yersinia enterocolitica strains
Pathogenic bacteria Yersinia enterocolitica injects virulence plasmid-encoded effectors through the type three secretion system into macrophages to modulate gene expression. Here we analyzed the effect on gene expression in primary human macrophages of Y. enterocolitica strains lacking effector YopP...
ORGANISM(S): Homo sapiens 
2022-06-01 | E-MTAB-10602 | biostudies-arrayexpress
TranscriptomicsRNA-seq of primary human macrophages uninfected or infected with Yersinia enterocolitica strains
Pathogenic bacteria Yersinia enterocolitica injects virulence plasmid-encoded effectors through the type three secretion system into macrophages to modulate gene expression. At this point there are no comprehensive gene expression analysis in primary human macrophages analyzing the effect of virulen...
ORGANISM(S): Homo sapiens 
2021-11-07 | E-MTAB-10473 | biostudies-arrayexpress
GenomicsYersinia type three secretion system effectors cooperate to suppress the major immune pathways in primary human macrophages
Numerous bacterial pathogens utilize type 3 secretion systems that inject effector proteins into host immune cells to support their pathogenesis. We investigated the T3SS effectors (Yops) of Yersinia enterocolitica for their individual and combined effects on gene expression, inflammasome formation ...
ORGANISM(S): Homo sapiens 
2025-04-21 | E-MTAB-14995 | biostudies-arrayexpress
TranscriptomicsSuppression of the key immune pathways in primary human macrophages by cooperation of Yersinia effectors
In order to suppress the host immune system, numerous bacterial pathogens utilize a type 3 secretion system (T3SS) to inject effector proteins into target cells. We investigated Yersinia enterocolitica effectors (Yops) for their individual and combined effects on gene expression, inflammasome format...
ORGANISM(S): Homo sapiens 
2025-04-30 | E-MTAB-15035 | biostudies-arrayexpress
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