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MetabolomicsPKM2 methylation by CARM1 activates aerobic glycolysis to promote tumorigenesis
Metabolic reprogramming is a hallmark of cancer. Herein we discover that the key glycolytic enzyme pyruvate kinase M2 isoform (PKM2), but not the related isoform PKM1, is methylated by co-activator-associated arginine methyltransferase 1 (CARM1). PKM2 methylation reversibly shifts the balance of met...
2021-07-30 | MTBLS533 | MetaboLights
MetabolomicsSMAD3 and HIF-1α Orchestrate Metabolic Transition to Aerobic Glycolysis as a Critical Prerequisite for Spontaneous Reprogramming of Spermatogonial Stem Cells

Spermatogonial stem cells (SSCs) possess the capacity for spontaneous reprogramming during in vitro culture, while the underlying mechanisms remain poorly understood, especially why addition of epidermal growth factor (EGF), leukemia inhibitory factor (LIF) remarkably enhanced transition efficien...

2025-07-08 | MTBLS12698 | MetaboLights
MetabolomicsMetabolic programming and functional remodeling by a c-di-GMP-centric hierarchy in aerobic granular sludge

This study systematically elucidates the hierarchical signaling regulatory network in aerobic granular sludge (AGS) by integrating dynamic analysis of quorum sensing signal molecules, microbial community structure profiling, and metabolomic characterization. The research reveals that c-di-GMP fun...

2025-12-10 | MTBLS13486 | MetaboLights
MetabolomicsThe Effects of Combined Aerobic and Resistance Exercise on Liver Metabolomics in Mice Fed a High-Fat Diet

Background and Objectives: Obesity is often accompanied by hepatic metabolic disorders and chronic low-grade inflammation. While combined aerobic and resistance exercise is considered an intervention to improve body composition, its systematic regulatory effects on the hepatic metabolic profile r...

2026-07-11 | MTBLS15011 | MetaboLights
TranscriptomicsChromosomal Fragile Site FRA16D tumor suppressor gene Wwox contributes to aerobic metabolism and oxidative stress response
The WWOX gene spans chromosomal fragile site FRA16D, a region of DNA instability in cancer. While WWOX has some tumor suppressor characteristics, its normal role and functional contribution to cancer are unclear. Drosophila homozygous Wwox mutants are viable with no discernable phenotype. Drosophila...
ORGANISM(S): Drosophila melanogaster 
2010-12-07 | E-GEOD-22689 | biostudies-arrayexpress
MetabolomicsMitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis
Somatic DNMT3A R882 codon mutations drive the most common form of clonal haematopoiesis (CH) and are associated with increased acute myeloid leukaemia (AML) risk1,2. Preventing expansion of DNMT3A-R882-mutant haematopoietic stem/progenitor cells (HSPCs) may therefore avert progression to AML. To ide...
2025-02-06 | MTBLS12201 | MetaboLights
ProteomicsGlobal Lactylation Profiling Reveals Lactate-Driven Regulatory Mechanisms Promoting Tumor Progression in Oral Carcinoma
Cancer cells often rely on aerobic glycolysis for metabolism, and lactylation, a newly discovered post-translational modification, significantly impacts molecular processes. This study comprehensively analyzes lactylation's role in oral squamous cell carcinoma (OSCC), providing initial insights into...
ORGANISM(S): Homo sapiens (Human) 
2024-08-23 | PXD047673 | Pride
Human Proteome Oral cancer 
TranscriptomicsTranscription profiling of S. cerevisiae reveaks increasing nadh oxidation reduces overflow metabolism
When the yeast Saccharomyces cerevisiae is subjected to increasing glycolytic fluxes under aerobic conditions, there is a threshold value of the glucose uptake rate at which the metabolism shifts from being purely respiratory to mixed respiratory and fermentative. This shift is characterized by etha...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-14 | E-GEOD-6277 | biostudies-arrayexpress
ProteomicsAdaptation of Lacticaseibacillus rhamnosus CM MSU 529 to aerobic and respiratory growth: a proteomic approach
Lacticaseibacillus rhamnosus CM MSU 529 is the O2-tolerant facultative homofermentative lactic acid bacteria realizing respiratory metabolism when grown in a supplemented with hemin and vitamin K2 nutrient medium. This study describes the effect of aerobic and respiratory conditions on biomass and p...
ORGANISM(S): Lacticaseibacillus rhamnosus LRHMDP2 
2023-03-11 | PXD038847 | Pride
Lacticaseibacillus rhamnosus  aerobic conditions  respiratory conditions  oxidative stress  pyruvate oxidase  pyridoxine 5'-phosphate oxidase  nadh peroxidase  acetolactate synthase 
TranscriptomicsLocust flight muscle: Tibetan Plateau population vs. North China Plain population
Background: Responses to hypoxia have been investigated in many species; however, comparative study between conspecific geographical populations in different altitude regions is rare, especially for invertebrates . The migratory locust, Locusta migratoria, is widely distributed both on high-altitude...
ORGANISM(S): Locusta migratoria 
2013-12-24 | E-GEOD-43327 | biostudies-arrayexpress
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