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TranscriptomicsActivation of peroxisome proliferator-activated receptor alpha in human peripheral blood mononuclear cells
Background: Peripheral blood mononuclear cells (PBMCs) are relatively easily obtainable cells in humans. Gene expression profiles of PBMCs have been shown to reflect the pathological and physiological state of a person. Recently, we showed that the nuclear receptor peroxisome proliferator-activated ...
ORGANISM(S): Homo sapiens 
2008-06-06 | E-GEOD-11289 | biostudies-arrayexpress
TranscriptomicsHigh fat challenges with different fatty acids affect distinct atherogenic gene expression pathways in immune cells from lean and obese subjects
Early perturbations in vascular health can be detected by imposing subjects to a high fat (HF) challenge and measure response capacity. Subtle responses can be determined by assessment of whole-genome transcriptional changes. We aimed to magnify differences in health by comparing gene-expression cha...
ORGANISM(S): Homo sapiens 
2015-05-13 | E-GEOD-53232 | biostudies-arrayexpress
TranscriptomicsDifferences in genome-wide gene expression response in PBMCs between young and old men upon caloric restriction
Caloric restriction (CR) is considered to increase lifespan and to prevent various age-related diseases in different non-human organisms. Only a limited number of CR studies have been performed in humans, and results put CR as a beneficial tool to decrease risk factors in several age-related disease...
ORGANISM(S): Homo sapiens 
2016-10-24 | E-GEOD-63117 | biostudies-arrayexpress
TranscriptomicsEffects of a diet high in monounsaturated fat and a full Mediterranean diet on PBMC whole genome gene expression and plasma proteins
This study aimed to identify the effects of replacement of saturated fat (SFA) by monunsaturated fat (MUFA) in a western-type diet and the effects of a full Mediterranean (MED) diet on whole genome PBMC gene expression and plasma protein profiles. Abdominally overweight subjects were randomized to a...
ORGANISM(S): Homo sapiens 
2012-08-02 | E-GEOD-30509 | biostudies-arrayexpress
TranscriptomicsPolyunsaturated fatty acids acutely affect triacylglycerol-derived skeletal muscle fatty acid uptake and increases postprandial insulin sensitivity
Dietary fat quality may influence skeletal muscle lipid handling and fat accumulation, thereby modulating insulin sensitivity. Objective: To examine acute effects of meals with various fatty acid (FA) compositions on skeletal muscle FA handling and postprandial insulin sensitivity in obese insulin r...
ORGANISM(S): Homo sapiens 
2012-02-21 | E-GEOD-31901 | biostudies-arrayexpress
TranscriptomicsFish oil supplementation induces anti-atherogenic gene expression profiles in human blood mononuclear cells
Fish oil supplementation is generally seen as beneficial for human health, due to the presence of n-3 polyunsaturated fatty acids (n-3 PUFAs). These fatty acids can elicit their effect through changes in gene expression. Effects of n-3 PUFAs on gene expression of inflammatory and atherogenic markers...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-12375 | biostudies-arrayexpress
TranscriptomicsA saturated fatty acid rich diet can induce an 'obese-like' gene expression profile in adipose tissue
We investigated the effect of a saturated (SFA) and a monounsaturated (MUFA) rich diet on insulin sensitivity and adipose tissue gene expression profiles of subjects at risk for metabolic syndrome. A controlled-feeding trial was performed with 20 moderately overweight subjects. Subjects received a S...
ORGANISM(S): Homo sapiens 
2010-02-13 | E-GEOD-14954 | biostudies-arrayexpress
TranscriptomicsEffects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men
Polyphenolic compounds, such as resveratrol, have recently received widespread interest due to their ability to mimic effects of calorie restriction. The objective of the present study was to gain more insight into the effects of 30 days resveratrol supplementation on adipose tissue morphology and u...
ORGANISM(S): Homo sapiens 
2013-09-25 | E-GEOD-42432 | biostudies-arrayexpress
UnknownDiscriminating Dietary Responses by Combining Transcriptomics and Metabolomics Data in Nutrition Intervention Studies.
Not available
S-EPMC8221028 | biostudies-literature
UnknownImpact of a 12-week personalized dietary intervention on vascular function and cardiovascular risk factors.
Not available
S-EPMC11965023 | biostudies-literature
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