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TranscriptomicsPoly(A)-specific ribonuclease (PARN) mediates 3' end maturation of the telomerase RNA component
Mutations in the poly(A) ribonuclease (PARN) gene cause telomere diseases including familial idiopathic pulmonary fibrosis (IPF) and dyskeratosis congenita (DC)1,2, but how PARN deficiency impacts telomere maintenance is unclear. Here, using somatic cells and induced pluripotent stem (iPS) cells fro...
ORGANISM(S): Homo sapiens 
2015-09-08 | E-GEOD-71709 | biostudies-arrayexpress
TranscriptomicsPost-transcriptional manipulation of TERC reverses molecular hallmarks of telomere disease
The telomerase RNA component (TERC) is a critical determinant of cellular self renewal. Poly(A)-specific ribonuclease (PARN) is required for post-transcriptional maturation of TERC. PARN mutations lead to incomplete 3′ end processing and increased destruction of nascent TERC RNA transcripts, resul...
ORGANISM(S): Homo sapiens 
2016-08-02 | E-GEOD-81507 | biostudies-arrayexpress
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