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GenomicsThe reverse transcriptase inhibitor 3TC protects against age-related cognitive dysfunction
The reverse transcriptase inhibitor 3TC protects against age-related cognitive dysfunction
PRJNA882769 | ENA
TranscriptomicsDeep Sleep and Parietal Cortex Gene Expression Changes are Related to Cognitive Deficits with Age
Background: Age-related cognitive deficits negatively affect quality of life and can presage serious neurodegenerative disorders. Despite sleep disruption’s well-recognized negative influence on cognition, and its prevalence with age, surprisingly few studies have tested sleep’s relationship to cogn...
ORGANISM(S): Rattus norvegicus 
2011-04-21 | E-GEOD-24515 | biostudies-arrayexpress
TranscriptomicsIncreased Human like Alzheimer features in a Novel Mouse Model with Oxidative DNA Repair Dysfunction
The decline of cognitive function is a feature of normal human aging and is exacerbated in AlzheimerM-bM-^@M-^Ys disease (AD). DNA repair declines in brain cells during normal aging and even more so in AD. Here we show that experimental reduction in levels of the base excision repair enzyme, DNA ...
ORGANISM(S): Mus musculus 
2015-01-05 | E-GEOD-60911 | biostudies-arrayexpress
TranscriptomicsThe reverse transcriptase inhibitor 3TC protects against age-related cognitive dysfunction
Aging is the primary risk factor for most neurodegenerative diseases, including Alzheimer's disease. Major hallmarks of brain aging include neuroinflammation/immune activation and reduced neuronal health/function. These processes contribute to cognitive dysfunction (a key risk factor for Alzheimer's...
ORGANISM(S): Mus musculus 
2023-03-23 | GSE213848 | GEO
ProteomicsPrimary Cilia-Autophagy Axis in Hippocampal Neurons Is Essential to Maintain Cognitive Fitness
A central hallmark of brain aging is the alteration of neuronal functions in the hippocampus, leading to a progressive decline in learning and memory. Multiple reports have shown the importance of blood-borne factors in inter-tissue communication for the maintenance of cognitive fitness and proper r...
ORGANISM(S): Mus musculus (Mouse) 
2024-11-07 | PXD056975 | Pride
Autophagy Age-related cognitive dysfunction Synaptic plasticity Hippocampus Primary cilium (pc) Osteocalcin (ocn) 
TranscriptomicsTranscription profiling of brains from cognitively impaired and unimpaired old rats and young rats at zero or 21 days post water maze training, and untrained individuals
Although immediate early genes (IEGs) such as Bdnf, Arc and Egr1, have been implicated in plasticity, the larger pathways related to memory and memory disorders are not well understood. Here, we combined statistical Affymetrix microarray and behavioral analyses to identify key genes and pathways ass...
ORGANISM(S): Rattus norvegicus 
2007-11-29 | E-GEOD-5666 | biostudies-arrayexpress
GenomicsWhole-Body Senescent Cell Clearance Alleviates Age-Related Brain Inflammation and Cognitive Impairment in Mice
Whole-Body Senescent Cell Clearance Alleviates Age-Related Brain Inflammation and Cognitive Impairment in Mice
PRJNA677926 | ENA
MetabolomicsWhole blood metabolomics of dementia patients reveal classes of disease-linked metabolites

Dementia is caused by factors that damage neurons. We quantified small molecular markers in whole blood of dementia patients, using non-targeted liquid chromatography-mass spectroscopy (LC-MS). Thirty-three metabolites, classified into 5 groups (A-E), differed significantly in dementia patients, ...

2021-07-06 | MTBLS2109 | MetaboLights
GenomicsDepletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [scRNA-seq]
Depletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [scRNA-seq]
PRJNA1471026 | ENA
GenomicsDepletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ChIP-Seq]
Depletion of endothelial KLF4 drives age-related neurovascular dysfunction and neuropsychiatric impairment [ChIP-Seq]
PRJNA1471016 | ENA
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