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MetabolomicsMetabolomic Signature of Early Vascular Aging (EVA) in Hypertension

Arterial stiffening is a hallmark of early vascular aging (EVA) syndrome and an independent predictor of cardiovascular morbidity and mortality. In this case-control study we sought to identify plasma metabolites associated with EVA syndrome in the setting of hypertension. An untargeted metabolom...

2020-01-14 | MTBLS1359 | MetaboLights
ProteomicsIntegrated analysis of proteomics on rat hearts with aging and hypertension
Hypertension is a most important risk factor of cardiovascular diseases (CVD), and its incidence is greatest among older adults, which indicates that aging is an independent risk for both hypertension and CVD. To date, the studies on the proteomics and phosphoproteomics of the aged hypertensive hear...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-06-18 | PXD026773 | Pride
Aging and hypertension Rat Tmt Heart Lc-ms/ms 
ProteomicsIntegrated analysis of proteomics and phosphoproteomics on rat hearts with aging and hypertension
Hypertension is a most important risk factor of cardiovascular diseases (CVD), and its incidence is greatest among older adults, which indicates that aging is an independent risk for both hypertension and CVD. To date, the studies on the proteomics and phosphoproteomics of the aged hypertensive hear...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-06-18 | PXD026608 | Pride
Aging and hypertension Phosphoproteome Rat Heart Lc-ms/ms 
MetabolomicsA molecular index for biological age identified from the metabolome and senescence-associated secretome in humans.
Unlike chronological age, biological age is a strong indicator of health of an individual. However, the molecular fingerprint associated with biological age is ill-defined. To define a high-resolution signature of biological age, we analyzed metabolome, circulating senescence-associated secretome (S...
2024-01-24 | MTBLS1991 | MetaboLights
UnknownKorea hypertension fact sheet 2022: analysis of nationwide population-based data with a special focus on hypertension in the elderly.
Not available
S-EPMC10426053 | biostudies-literature
ProteomicsCD4+ T cell specific proteomic pathways identified in progression of hypertension across postmenopausal transition
Menopause is associated with an increase in the prevalence and severity of hypertension in women. Although premenopausal females are protected against T cell-dependent immune activation and development of angiotensin II (Ang II) hypertension, this protection is lost in postmenopausal females. Theref...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD021233 | Pride
Postmenopausal hypertension cd4+ t cell 
UnknownInsulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.
Not available
S-EPMC5418199 | biostudies-literature
GenomicsPodocyte Aging with and without Hypertension: A Comparative Study in Young and Middle-Aged Mice
Podocyte Aging with and without Hypertension: A Comparative Study in Young and Middle-Aged Mice
PRJNA1181818 | ENA
GenomicsGut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes
Gut microbial DNA and immune checkpoint gene Vsig4/CRIg are key antagonistic players in healthy aging and age-associated development of hypertension and diabetes
PRJNA897008 | ENA
TranscriptomicsTranscription profiling of monkey aorta to examine aging and gender effects
Although increased vascular stiffness is more prominent in aging males than females, and males are more prone to vascular disease with aging, no study has investigated the genes potentially responsible for gender differences in vascular aging. We tested the hypothesis that the transcriptional adapt...
ORGANISM(S): Macaca fascicularis 
2008-06-15 | E-GEOD-6599 | biostudies-arrayexpress
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