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TranscriptomicsUNRAVELING A NOVEL TRANSCRIPTION FACTOR CODE INDUCTIVE FOR THE HUMAN ARTERIAL-SPECIFIC ENDOTHELIAL CELL SIGNATURE
Endothelial cells (EC) lining arteries and veins have distinct molecular and functional signatures. The (epi)genetic regulatory mechanisms underlying this heterogeneity in human EC are incompletely understood. Using genome-wide microarray screening we established a specific fingerprint of freshly is...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-GEOD-43475 | biostudies-arrayexpress
TranscriptomicsThe HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model
This SuperSeries is composed of the following subset Series: GSE26789: The HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model (ALL-B and ALL-T) GSE26790: The HDAC inhibitor panobinostat (LBH589) inhibits A...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-26807 | biostudies-arrayexpress
TranscriptomicsWhole DNA methylome of an extramedullary multiple myeloma patient derived orthotopic xenograft
A patient derived orthotopic xenograft (PDOX) was generated from a patient with an 53 aggressive extramedullary multiple myeloma (EMM) to study in-depth genetic and epigenetic events and drug responses related to extramedullary disease. Whole DNA methylome of the EMM PDOX was also evaluated and comp...
ORGANISM(S): Homo sapiens 
2021-06-25 | E-MTAB-10654 | biostudies-arrayexpress
UnknownFirst case of highly pathogenic H5N1 avian influenza virus in Spain.
Not available
S-EPMC2621144 | biostudies-literature
UnknownReproducibility dataset for a large experimental survey on word embeddings and ontology-based methods for word similarity.
Not available
S-EPMC6736772 | biostudies-literature
TranscriptomicsThe HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model (TOM-1 and MOLT-4)
Histone deacetylases (HDACs) have been identified as therapeutic targets due to regulatory function in DNA structure and organization. We have analyzed the role of the LBH589, a novel pan inhibitor of class I and II HDACs, in Acute Lymphoblastic Leukemia. In vitro, LBH589 was shown to induce a dose...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-26790 | biostudies-arrayexpress
TranscriptomicsA Novel Tumor suppressor network in squamous malignancies
The specific ablation of Rb1 gene in stratified epithelia (RbF/F;K14cre) promotes proliferation and altered differentiation but is insufficient to produce spontaneous tumors. The pRb relative, p107, compensates some of the functions of pRb in these tissues, however RbF/F;K14cre;p107-/- mice die post...
ORGANISM(S): Mus musculus 
2012-12-21 | E-GEOD-38257 | biostudies-arrayexpress
TranscriptomicsThe HDAC inhibitor panobinostat (LBH589) inhibits Acute Lymphoblastic leukemia (ALL) in vitro and in vivo in a new characterized human ALL mice model (ALL-B and ALL-T)
Histone deacetylases (HDACs) have been identified as therapeutic targets due to regulatory function in DNA structure and organization. We have analyzed the role of the LBH589, a novel pan inhibitor of class I and II HDACs, in Acute Lymphoblastic Leukemia. In vitro, LBH589 was shown to induce a dose...
ORGANISM(S): Homo sapiens 
2012-04-17 | E-GEOD-26789 | biostudies-arrayexpress
UnknownThe structure of the AliC GH13 α-amylase from Alicyclobacillus sp. reveals the accommodation of starch branching points in the α-amylase family.
Not available
S-EPMC6333287 | biostudies-literature
UnknownIris: Interactive all-in-one graphical validation of 3D protein model iterations.
Not available
S-EPMC7737763 | biostudies-literature
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