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TranscriptomicsEvolution of virulence control by the staphylococcal agr quorum-sensing regulator
The Staphylococcus aureus accessory gene regulator (agr) is a prototype quorum-sensing system in Gram-positive bacteria and a paradigmatic example of gene regulation by a small regulatory RNA, RNAIII. Using genome-wide transcriptional profiling in the community-associated methicillin-resistant (CA-M...
ORGANISM(S): Staphylococcus aureus 
2010-05-14 | E-GEOD-10165 | biostudies-arrayexpress
TranscriptomicsRole of the accessory gene regulator agr in community-associated MRSA pathogenesis
The success of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) as pathogens is due to a combination of antibiotic resistance with high virulence. However, evolution of the exceptional virulence potential of CA-MRSA is not understood. Our previous study indicated that diffe...
ORGANISM(S): Staphylococcus aureus 
2011-03-29 | E-GEOD-18793 | biostudies-arrayexpress
TranscriptomicsA point mutation in the agr locus caused previously reported phenotypes in Staphylococcus aureus pneumonia
The role of Pantonâ??Valentine leukocidin (PVL) in Staphylococcus aureus pathogenesis is controversial. Here, we show that an unintended point mutation in the agr P2 promoter of S.aureus caused the phenotypes in gene regulation and murine pneumonia attributed to PVL by Labandeiraâ??Rey et al. (Scien...
ORGANISM(S): Staphylococcus aureus 
2010-05-16 | E-GEOD-14394 | biostudies-arrayexpress
GenomicsThe quorum-sensing agr system protects Staphylococcus aureus from oxidative stress (overnight growth)
The quorum-sensing agr system protects Staphylococcus aureus from oxidative stress (overnight growth)
PRJNA852598 | ENA
GenomicsThe quorum-sensing agr system protects Staphylococcus aureus from oxidative stress (5 hour growth)
The quorum-sensing agr system protects Staphylococcus aureus from oxidative stress (5 hour growth)
PRJNA852568 | ENA
GenomicsImpact of the Staphylococcus aureus agr quorum sensing system on the lifecycle of the Sa3int temperate phage
Staphylococcus aureus agr quorum sensing system and Sa3int temperate phage
PRJEB89906 | ENA
ProteomicsSilence as a way of niche adaptation: mecC-MRSA with variations in the accessory gene regulator (agr) functionality express kaleidoscopic phenotypes
Functionality of the accessory gene regulator (agr) quorum sensing system is an important switch promoting either acute or chronic infections, mediated by the notorious opportunistic human and veterinary pathogen Staphylococcus aureus. Spontaneous alterations of the agr system are known to frequentl...
ORGANISM(S): Staphylococcus aureus 
2021-09-09 | PXD016486 | Pride
Bacteria Mecc-mrsa S. aureus 
TranscriptomicsThe quorum-sensing agr system protects Staphylococcus aureus from oxidative stress (overnight growth)
The agr quorum-sensing system clearly links Staphylococcus aureus metabolism to virulence, but little is known about how agr alters metabolism to affect cell survival during severe stress. Recently, we reported that agr activity increases survival of bacteria during treatment with lethal concentrati...
ORGANISM(S): Staphylococcus aureus 
2023-06-20 | GSE206916 | GEO
GenomicsMouR controls the expression of the Listeria monocytogenes Agr system and mediates virulence
MouR controls the expression of the Listeria monocytogenes Agr system and mediates virulence
PRJNA418154 | ENA
TranscriptomicsSingle-cell approach dissecting agr quorum sensing dynamics in Staphylococcus aureus
RNAseq of exponentially growing cultures of the four agr prototype strains used in the study to investigate if differential expression of regulators interacting with the agr system could explain the differences in AIP sensitivity. Abstract Staphylococcus aureus both colonizes humans and causes seve...
ORGANISM(S): Staphylococcus aureus 
2024-03-05 | E-MTAB-13859 | biostudies-arrayexpress
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