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TranscriptomicsExpression profiles of EDTA-dissociated colon epithelial cells of wild-type mice and vil-Cre-Bcl9-/-/Bcl9l-/- mice.
To assess potential changes in Wnt signaling more comprehensively, EDTA-dissociated colon epithelial cells from three pools of wild-type and Bcl9/Bcl9l-mutant mice were subjected to an exploratory comparative gene expression profiling. Total RNA of three samples of EDTA-dissociated colon epithelial ...
ORGANISM(S): Mus musculus 
2010-09-01 | E-GEOD-21549 | biostudies-arrayexpress
TranscriptomicsExpression profiles of laser dissected colon tumor samples of wild-type mice and vil-Cre-Bcl9-/-/Bcl9l-/- mice
To investigate the impact of ablating Bcl9/Bcl9l on tumorigenesis, 6-8- week-old mice were exposed first to a single dose dimethylhydrazine (DMH, 44 mg/kg body weight), which is metabolized in the liver to carcinogenic azoxymethane (AOM), followed by 7 days oral administration of 2 % dextrane sulfat...
ORGANISM(S): Mus musculus 
2010-09-01 | E-GEOD-21576 | biostudies-arrayexpress
TranscriptomicsEstablishment of objective criteria for selecting relevant intestinal cell-based models
The objective of this study was to make use of gene expression signatures and functional assays to delineate differences between various intestinal colon carcinoma cell lines and normal intestinal epithelium to assess their appropriateness as a tumor model or for drug absorption studies. [Cell lines...
ORGANISM(S): Homo sapiens 
2012-06-23 | E-GEOD-30292 | biostudies-arrayexpress
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