Sort   by:  
 Page size 
UnknownLack of pairing during meiosis triggers multigenerational transgene silencing in Caenorhabditis elegans.
Not available
S-EPMC4443339 | biostudies-literature
UnknownGerm granule dysfunction is a hallmark and mirror of Piwi mutant sterility.
Not available
S-EPMC7930041 | biostudies-literature
UnknownGametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations.
Not available
S-EPMC7862594 | biostudies-literature
UnknownCaenorhabditis elegans RSD-2 and RSD-6 promote germ cell immortality by maintaining small interfering RNA populations.
Not available
S-EPMC4205660 | biostudies-literature
UnknownTransgenerational Sterility of Piwi Mutants Represents a Dynamic Form of Adult Reproductive Diapause.
Not available
S-EPMC5918633 | biostudies-literature
UnknownReduced insulin/IGF-1 signaling restores germ cell immortality to Caenorhabditis elegans Piwi mutants.
Not available
S-EPMC4049074 | biostudies-literature
TranscriptomicspiRNAs can trigger a multigenerational epigenetic memory in the germline of C. elegans
Transgenerational effects likely have wide-ranging implications for human health, biological adaptation and evolution, however their mechanism and biology remain poorly understood. Here we demonstrate that a germline nuclear small RNA/chromatin pathway can maintain epi-allelic inheritance for many g...
ORGANISM(S): Caenorhabditis elegans 
2012-06-25 | E-GEOD-38813 | biostudies-arrayexpress
ModelsStokes2020 - Antibiotics discovery using deep learning approach (Antiviral implementation)
This model was developed to support the early efforts in the identification of novel drugs against SARS-CoV2. It predicts the probability that a small molecule inhibits SARS-3CLpro-mediated peptide cleavage. It was developed using a high-throughput screening against the 3CL protease of SARS-CoV1, as...
2024-05-08 | MODEL2405080006 | BioModels
Machine Learning Model Ersilia 
ModelsStokes2020 - Antibiotics discovery using deep learning approach.
Based on a simple E.coli growth inhibition assay, the authors trained a model capable of identifying antibiotic potential in compounds structurally divergent from conventional antibiotic drugs. One of the predicted active molecules, Halicin (SU3327), was experimentally validated in vitro and in vivo...
2024-04-22 | MODEL2404080001 | BioModels
Machine Learning Model Ersilia 
UnknownGenomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis.
Not available
S-EPMC9646734 | biostudies-literature
Sort   by:  
 Page size