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TranscriptomicsDeep sequencing identifies PD0325901 modulated microRNAs in the J1 mESCs
PD0325901 is involved in improving reprogramming efficiency during inducing pluripotent stem cells (iPSC) or maintain a blastocyst-like state in embryonic stem cells (ESC). However, the knowledge about this small molecule regulating miRNAs in ESC was limited. To understand the role of miRNAs during ...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-67570 | biostudies-arrayexpress
TranscriptomicsIdentifying PD0325901-regulated genes in the J1 mESCs
It has been demonstrated that PD0325901 promotes self-renewal of mouse embryonic stem cells, however, the target genes of PD0325901 are not fully understood. To better understand the downstream target genes of PD0325901, we performed Microarray analyses to identify their downstream targets. The data...
ORGANISM(S): Mus musculus 
2016-05-17 | E-GEOD-67534 | biostudies-arrayexpress
TranscriptomicsAICAR can modulate the expression of microRNA in J1 mESC
We have demonstrated AICAR can maintain J1 mouse ES cells pluripotency in our previous research, yet its effects on ES cells miRNAs expression remain a mystery. In this study, we performed small RNA (sRNA) High-throughput sequencing using Illumina HiSeq 2000 to investigate the influence of AICAR on ...
ORGANISM(S): Mus musculus 
2014-02-06 | E-GEOD-54586 | biostudies-arrayexpress
TranscriptomicsIdentifying vitamin C and RA-regulated genes in the J1 mESCs
It has been demonstrated that vitamin C enhances reprogramming efficiency during inducing pluripotent stem cells, however, the underlying mechanisms are not fully understood. To find the downstream target genes of vitamin C and investigate the mechanism of vitamin C on reprogramming promotion, we pe...
ORGANISM(S): Mus musculus 
2014-01-21 | E-GEOD-43405 | biostudies-arrayexpress
TranscriptomicsIdentifying CHIR99021 and AICAR-regulated genes in the J1 mESCs
It has been demonstrated that CHIR99021 promotes self-renewal of mouse embryonic stem cells, however, the target genes of CHIR99021 is not fully understood. AICAR is the activator of AMP-activated protein kinase. It is reported that AICAR plays important role in mouse embryonic stem cells, however t...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-40959 | biostudies-arrayexpress
UnknownTowards precision medicine based on a continuous deep learning optimization and ensemble approach.
Not available
S-EPMC9898519 | biostudies-literature
ProteomicsTalaroconvolutin-A treated bladder cancer for proteomics sequencing
TalaA inhibits bladder cancer mainly through two approaches: 1) arresting cell cycle to suppress proliferation, 2) triggering ferroptosis to cause cell death. In molecular mechanism, TalaA can interact with MAPKs to repress the phosphorylation of transcription regulators. This study would open new a...
ORGANISM(S): Homo Sapiens 
2022-10-27 | PXD037785 |
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