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ProteomicsVersican regulates Collagen fibrillation and Tenascin-C expression, suppressing podosome formation and pulmonary fibrosis
The activation and accumulation of lung fibroblasts, leading to aberrant deposition of extracellular matrix (ECM) components, is a pathogenic hallmark of Idiopathic Pulmonary Fibrosis (IPF), a lethal and currently incurable disease. ECM deposition perpetuates fibroblast activation and stimulates ECM...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD060583 | Pride
Pulmonary fibrosis  extracellular matrix (ecm)  lung fibroblasts  podosomes  ecm invasion  versican (vcan)  hyaluronan (ha)  collagen (col)  tenascin-c (tnc) 
TranscriptomicsTranscription profiling of synovial fibroblast ex vivo cultures or whole joints (J), isolated from arthritic mice (197, DARE) and their corresponding normal (F1, wt) littermates
GOAL: Identification of genes and/or pathways involved in the pathogenesis of animal models of Rheumatoid Arthritis (RA). Total RNA samples were extracted from synovial fibroblast ex vivo cultures or whole joints (J), isolated from arthritic mice (197, DARE) and their corresponding normal (F1, wt) l...
ORGANISM(S): Mus musculus 
2005-06-30 | E-MEXP-255 | biostudies-arrayexpress
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