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TranscriptomicsExpression data from adult Myeloerythroid Progenitors (MP) ICN2 positive and adult Myeloerythroid Progenitors (MP) ICN2 negative
Notch signaling defines a conserved, fundamental pathway, responsible for determination in metazoan development and is widely recognized as an essential component of lineage specific differentiation and stem cell self-renewal in many tissues including the hematopoietic system. Until recently, the ma...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46724 | biostudies-arrayexpress
TranscriptomicsExpression data from adult Myeloerythroid Progenitors (MP) Hes1-GFP positive and adult Myeloerythroid Progenitors (MP) Hes1-GFP negative
Notch signaling defines a conserved, fundamental pathway, responsible for determination in metazoan development and is widely recognized as an essential component of lineage specific differentiation and stem cell self-renewal in many tissues including the hematopoietic system. Until recently, the ma...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46723 | biostudies-arrayexpress
TranscriptomicsExpression data from E13.5 Fetal Liver LSK Hes1-GFP positive and E13.5 Fetal Liver LSK Hes1-GFP negative
Notch signaling defines a conserved, fundamental pathway, responsible for determination in metazoan development and is widely recognized as an essential component of lineage specific differentiation and stem cell self-renewal in many tissues including the hematopoietic system. Until recently, the ma...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46725 | biostudies-arrayexpress
TranscriptomicsExpression data from adult LSK Hes1-GFP positive and adult LSK Hes1-GFP negative
Notch signaling defines a conserved, fundamental pathway, responsible for determination in metazoan development and is widely recognized as an essential component of lineage specific differentiation and stem cell self-renewal in many tissues including the hematopoietic system. Until recently, the ma...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46722 | biostudies-arrayexpress
TranscriptomicsIn Vivo Mapping of Notch Pathway Activity in Normal and Stress Hematopoiesis
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-46726 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse gain- and loss-of-function Hedgehod (Hh) genetic models reveals Hedgehog signaling is dispensable for adult hematopoietic stem cell function
The Hedgehog (Hh) signaling pathway is a developmentally conserved regulator of stem cell function. Several reports suggested that Hh signaling is an important regulator of hematopoietic stem cell (HSC) maintenance and differentiation. Here we test this hypothesis in vivo using both gain- and loss-o...
ORGANISM(S): Mus musculus 
2009-03-21 | E-GEOD-15194 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Fbw7-/-/hematopoietic stem cells
Ubiquitination is a post-translational mechanism of control of diverse cellular processes. We focus here on the ubiquitin ligase Fbw7, a recently identified hematopoietic tumor suppressor that can target for degradation several important oncogenes including Notch1, c-Myc and cyclin E. We have genera...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-11178 | biostudies-arrayexpress
GenomicsHistone chromatin modifications in control and Med12-deficient mouse HSPCs
Using iChIP, we map H3K27Ac, H3K4me3 and H3K4me1 in small populations (HSPCs) in the presence or absence of Med12 and identify affected super-enhancers. iChIP was performed using previously published protocols (Lara-Astiaso et al, 2014 Immunogenetics. Chromatin state dynamics during blood formation ...
ORGANISM(S): Mus musculus 
2016-08-25 | E-GEOD-76052 | biostudies-arrayexpress
GenomicsTet1 is a tumor suppressor of hematopoietic malignancy
Epigenetic pathways that regulate DNA methylation and chromatin modifications are frequently found to be dysregulated in human cancers. The TET methylcytosine dioxygenase 1 (TET1) enzyme is an important regulator of hydroxymethylcytosine (5hmC) in embryonic stem cells, neural progenitors,adult cells...
ORGANISM(S): Mus musculus 
2015-04-12 | E-GEOD-65895 | biostudies-arrayexpress
TranscriptomicsExpression data from vehicle or PD-0332991 treated human T-ALL lines
Cyclin D3 is critical hematopoiesis and loss of cyclin D3 leads to resistance to transformation of bone marrow progenitors by Notch1-IC. We used a small molecule targeting cyclin D3:CDK4/6 activity to study whether its inhibition is an effective therapeutic strategy. We analyzed T-ALL lines in vitro...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-40635 | biostudies-arrayexpress
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