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The up-dosing phase is marked by increased IL-10+B-cells with allergen-specific PD-L1 up-regulation, while effector Th1/Th17 cells and CCR6+IL-17+FoxP3+T-cells decrease. The conversion phase exhibits Th17 recovery in the absence of Th2cells. The tolerance-mounting phase after three years of treatmen...
ORGANISM(S): Homo sapiens 
2018-10-29 | GSE118243 | GEO
Early regulatory B cell induction and Th/Tr17 responses relates to success of long-term grass-pollen AIT
Vaccinium macrocarpon strain:Bergmen | cultivar:Ait Transcriptome or Gene expression
Allergen-specific immunotherapy (AIT) is able to restore immune tolerance to allergens in allergic patients. However, some patients do not or only poorly respond to current treatment protocols. Therefore, there is a need for deeper mechanistic insights and further improvement of treatment strategies...
ORGANISM(S): Mus musculus 
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