The phylogenetic divergence between parasitic and mammalian phosphoglycerate mutases (PGMs) offers an opportunity for selective pharmacologic targeting of glycolysis in disease-causing organisms. With this aim we previously described ipglycermides, discovered by affinity selection from a vast nuclei...
ORGANISM(S): Brugia malayi Dirofilaria immitis Escherichia coli Onchocerca volvulus Caenorhabditis elegans
