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TranscriptomicsGenome-wide analysis of early transcriptional events induced by cytokine IL-4 in human cord blood CD4+ T cells
The aim of this dataset was to study in detail the transcription kinetics initiated by cytokine IL-4 in early differentiation of Th2 cells. Total RNA obtained from activated and IL-4 & anti-IL-12 treated cord blood CD4+ T cells, 0.5, 1, 2, 4, 6, 12, 24, 48, and 72 hours after initiation of the cultu...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-17974 | biostudies-arrayexpress
TranscriptomicsMicroarray gene expression analysis of T-cell prolymphocytic leukemia (T-PLL) patient samples
T-cell prolymphocytic leukemia (T-PLL) is a rare and aggressive neoplasm of mature T-cells with an urgent need for rationally designed therapies to address its notoriously chemo-refractory behavior. To characterize the gene expression profiles, 12 T-PLL MNC samples (>90% tumor cell content) were scr...
ORGANISM(S): Homo sapiens 
2017-09-08 | E-MTAB-5916 | biostudies-arrayexpress
GenomicsGenome-wide detection of STAT6 binding sites in IL-4 treated naive human CD4+ T cells
STAT6 is a major transcription factor driving the polarization of Th2 cells in response to IL-4. STAT6 is phosphorylated by Jak1 and Jak3 kinases at the IL-4 receptor, after which phosphorylated STAT6 forms a homodimer and translocates into the nucleus. There STAT6 binds to specific DNA sequences, r...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-17850 | biostudies-arrayexpress
TranscriptomicsStat6 mediated regulation of transcription to initiate Th2 program in human T cells
This SuperSeries is composed of the following subset Series: GSE17850: Genome-wide detection of STAT6 binding sites in IL-4 treated naive human CD4+ T cells GSE17851: Genome-wide analysis of STAT6 target genes in IL-4 treated human cord blood CD4+ cells GSE17974: Genome-wide analysis of early transc...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-18017 | biostudies-arrayexpress
UnknownResistance to immune checkpoint therapies by tumour-induced T-cell desertification and exclusion: key mechanisms, prognostication and new therapeutic opportunities.
Not available
S-EPMC10575907 | biostudies-literature
UnknownHyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.
Not available
S-EPMC11014662 | biostudies-literature
UnknownDevelopment of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia.
Not available
S-EPMC8237267 | biostudies-literature
ProteomicsPP2A inhibition is a druggable MEK inhibitor resistance mechanism in KRAS-mutant lung cancer cells
TiO2-enriched and non-enriched samples and a pooled TiO2-enriched alkaline phosphatase treated sample from subconfluent A549 lung adenocarcinoma cells line. Cells were subjected to on of the 6 different treatments: Control sample, RNAi mediated depletion of PPP2R1A, CIP2A, or PME-1, and treatment w...
ORGANISM(S): Homo sapiens (Human) 
2018-10-11 | PXD009900 | Pride
Phosphoproteomics Pp2a A549 Lung cancer 
UnknownJAK/STAT-Activating Genomic Alterations Are a Hallmark of T-PLL.
Not available
S-EPMC6966610 | biostudies-literature
UnknownIntegrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity.
Not available
S-EPMC7098811 | biostudies-literature
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