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Genomicsena-DATASET-OSUCCC-31-10-2013-20:19:37:619-31 - samples
Whole genome sequencing data from Illumina platform were generated using 10 human cancer cell lines and 2 primary tumor samples. Nine of these samples contained fragments of human papillomavirus (HPV).
EGAD00001000691 | EGA
GenomicsGenome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability
Genomic instability is a hallmark of human cancers, including the 5% caused by human papillomavirus (HPV). Here we report a striking association between HPV integration and adjacent host genomic structural variation in human cancer cell lines and primary tumors. Whole genome sequencing revealed HPV ...
EGAS00001000599 | EGA
GenomicsHPV Virome Consortium Data Access Committee
Data Access Committee EGAC00001000141
EGAC00001000141 | EGA
TranscriptomicsLoss of Oncogenic Notch1 Contributes to PI3 Kinase Inhibitor Resistance in T Lineage Leukemia
Somatic NOTCH1 mutations are found in ~60% of T lineage acute lymphoblastic leukemias (T-ALLs). Notch1 is cleaved by γ secretase to generate activated Notch intracellular domain (NICD) proteins. The NOTCH1 mutations found in T-ALL constitutively activate Notch1 signaling by increasing NICD levels. G...
ORGANISM(S): Mus musculus 
2014-06-24 | E-GEOD-48260 | biostudies-arrayexpress
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