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TranscriptomicsThe DSIF subunits Spt4 and Spt5 have several unexpected, distinct roles in regulating immunoglobulin class switch recombination
Class-switch recombination (CSR), induced by activation-induced cytidine deaminase, can be divided into two phases: DNA cleavage of the switch (S) regions, and the joining of the cleaved ends of the different S regions. Here, we show that the DSIF complex (Spt4 and Spt5), a transcription elongation ...
ORGANISM(S): Mus musculus 
2013-10-22 | E-GEOD-33206 | biostudies-arrayexpress
TranscriptomicsTracing the conversion process for primordial germ cells to pluripotent stem cells
The overall gene expression profiles revealed by this system provide novel insight into how pluripotency is acquired in germ-committed cells. In the study presented here, we employed FACS sorting to purify pluripotent candidate cells during the culture period
ORGANISM(S): Mus musculus 
2012-04-24 | E-GEOD-37261 | biostudies-arrayexpress
TranscriptomicsAcetylated Histone Reader Brd4 functions as Repair Adaptor in Immunoglobulin Class Switch Recombination
Class Switch Recombination (CSR) is a B cell specific genomic alteration induced by activation induced cytidine deaminase (AID)-dependent DNA break, followed by repair and recombination at the immunoglobulin heavy-chain locus. The involvement of several chromatin-associated factors in promoting AID-...
ORGANISM(S): Mus musculus 
2014-06-20 | E-GEOD-52239 | biostudies-arrayexpress
ProteomicsProteomic analysis of ascites from LC and GC patients
Proteomic analysis by mass spectrometry was performed to characterize proteins in ascites samples from patients with gastric cancer (N = 7) or liver cirrhosis (N = 3).
ORGANISM(S): Homo Sapiens (human) 
2023-10-07 | PXD037200 | JPOST Repository
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