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TranscriptomicsAblation of Pten and Smad4 leads to metastatic lung carcinoma in a murine model.
Lung cancer is the leading cause of cancer related death in both men and women in the United States. Recently, Smad4 was discovered to be common somatic alteration in human squamous cell lung cancer. Our goal was to delineate the role of Smad4 in lung cancer. We have shown for the first time that t...
ORGANISM(S): Mus musculus 
2015-03-12 | E-GEOD-47116 | biostudies-arrayexpress
TranscriptomicsErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis [expression]
Lung cancer remains the leading cause of cancer death. Genome sequencing of lung tumors from patients with Squamous Cell Carcinoma has identified SMAD4 to be frequently mutated. Here we used a novel mouse model to determine the molecular mechanisms regulated by loss of Smad4 which lead to lung cance...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-57133 | biostudies-arrayexpress
GenomicsErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis [ChIP-seq]
Lung cancer remains the leading cause of cancer death. Genome sequencing of lung tumors from patients with Squamous Cell Carcinoma has identified SMAD4 to be frequently mutated. Here we used a novel mouse model to determine the molecular mechanisms regulated by loss of Smad4 which lead to lung cance...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-57177 | biostudies-arrayexpress
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