Sort   by:  
 Page size 
ProteomicsChemical and phosphoproteomics illuminate the cellular mode of action of AKT inhibitors
Due to its key role in dysregulated cellular signaling in cancer, AKT has been subject to intense drug discovery efforts leading to small molecule inhibitors investigated in clinical trials, notably breast cancer. To shed more light on how these drugs exert their therapeutic effects, we integrated c...
ORGANISM(S): Homo Sapiens 
2022-01-21 | PXD015188 | panorama
TranscriptomicsMetastable primordial germ cell-like state induced from mouse embryonic stem cells by Akt activation
Specification to primordial germ cells (PGCs) occurs under the mesoderm induction signals during gastrulation. Here, we found that Akt activation in embryonic stem (ES) cells generated self-renewing spheres during mesodermal differentiation induction and that the differentiation status of the spher...
ORGANISM(S): Mus musculus 
2010-04-30 | E-GEOD-18813 | biostudies-arrayexpress
TranscriptomicsHuman colorectal cancer cell lines treated with several inhibitors of PI3Kinase AKT signaling pathway
Signal transduction processes mediated by phosphatidyl inositol phosphates affect a broad range of cellular processes such as cell cycle progression, migration and cell survival. The protein kinase AKT is one of the major effectors in this signaling network. Chronic AKT activation contributes to onc...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-18005 | biostudies-arrayexpress
ProteomicsProtein abundance of AKT and ERK pathway components governs cell-type-specific regulation of proliferation
Signaling through the AKT and ERK pathways controls cell proliferation. However, the integrated regulation of this multistep process, involving signal processing, cell growth and cell-cycle progression, is poorly understood. Here we study different murine hematopoietic cell types, in which AKT and E...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080844 | MassIVE
TranscriptomicsTargeting the MTOR-AKT pathway in DLBCL
The mTOR (mammalian Target of Rapamycin) pathway is constitutively activated in Diffuse Large B-Cell Lymphoma (DLBCL). mTOR inhibition has been shown to have clinical activity in patients with DLBCL, although overall response rates remain low. We therefore evaluated differences in the transcriptome...
ORGANISM(S): Homo sapiens 
2012-04-29 | E-GEOD-27255 | biostudies-arrayexpress
ProteomicsCombined Inhibition of AKT and KIT Restores Expression of Programmed Cell Death 4 (PDCD4) in Gastrointestinal Stromal Tumor
AKT activation is a hallmark of IM resistance in GIST. The presence of an additional therapeutic agent could potentially suppress the growth and survival of a clone of cancer cells, which have developed resistance to IM. Simultaneous targeting of AKT in addition to inhibiting KIT with IM has potenti...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-01-20 | MSV000086739 | MassIVE
TranscriptomicsTranscription profiling of prostate cancer cells with Akt activation
To determine which genes may be regulated by Akt and participate in the transformation of cells, we have examined by microarray analyses genes turned on in the prostate cancer cell line, PC3, when Akt activity was induced. PC3 cells, which lack the lipid phosphatase PTEN, were treated overnight with...
ORGANISM(S): Homo sapiens 
2005-10-11 | E-SMDB-2030 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse prostate from AKT transgenic or wild type littermate controls treated with RAD001 (MTOR inhibition) or placebo reveals mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways reveals
Transgenic (Probasin driven Myr-AKT)or wild-type littermates were treated with RAD001 or placebo and sacrificed at 12 and 48 hours following the beginning of treatment
ORGANISM(S): Mus musculus 
2007-09-29 | E-GEOD-1413 | biostudies-arrayexpress
TranscriptomicsHGPalmer-PDX-NVP-TNKS656
Strong activation of the oncogenic Wnt/beta-catenin pathway is a main mechanism of resistance to FOXO3a-induced apoptosis promoted by PI3K and AKT inhibitors in colorectal cancer (CRC). Reducing Wnt/beta-catenin activity would sensitize colorectal tumors to these inhibitors. However, no Wnt/beta-cat...
ORGANISM(S): Homo sapiens 
2015-08-10 | E-MTAB-2446 | biostudies-arrayexpress
TranscriptomicsFOXO3a Is A Major Target Of Inactivation By PI3K/AKT Signaling In Aggressive Neuroblastoma
Neuroblastoma is a pediatric tumor of the peripheral sympathetic nervous system with a highly variable prognosis. Activation of the PI3K/AKT pathway in neuroblastoma is correlated with poor patient prognosis, but the precise downstream effectors mediating this effect have not been determined. Here, ...
ORGANISM(S): Homo sapiens 
2013-05-01 | E-GEOD-42762 | biostudies-arrayexpress
Sort   by:  
 Page size