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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
TranscriptomicsGene transcription profiling of Physcomitrella patens Pp_A_Doko#069 (DOKO69; Koprivova et al., 2004) protonema grown in liquid cultures.
Protonema of Physcomitrella patens Pp_A_Doko#069 (DOKO69; Koprivova et al., 2004) grown in liquid cultures with Knop medium (Reski and Abel, 1985) were harvested 6 days after last subculture and setting density to 120 mg/L dry weight.
ORGANISM(S): Physcomitrella patens 
2018-07-31 | E-MTAB-5374 | biostudies-arrayexpress
TranscriptomicsCardiac Gene Expression Profiling in CryAB R120G Transgenic Mice
Protein aggregation cardiomyopathy is a life-threatening manifestation of a multisystem disorder caused by the exchange mutation in the gene encoding the human small HSP ?B-crystallin (hR120GCryAB). Genetic studies in mice have established cardiac hR120GCryAB expression causes increased activity of...
ORGANISM(S): Mus musculus 
2008-12-12 | E-GEOD-9924 | biostudies-arrayexpress
MetabolomicsClovamide, a hydroxycinnamic acid amide, is a resistance factor against Phytophthora spp. in Theobroma cacao
The hydroxycinnamic acid amides (HCAAs) are a diverse group of plant specialized phenylpropanoid metabolites distributed widely in the plant kingdom and are known to be involved in tolerance to abiotic and biotic stress. The HCAA clovamide is reported in a small number of distantly related species. ...
2020-12-17 | MTBLS2154 | MetaboLights
TranscriptomicsRegulation of alternative splicing by the core spliceosomal machinery
Abstract: Alternative splicing (AS) plays a major role in the generation of proteomic diversity and in gene regulation. However, the role of the basal splicing machinery in regulating AS remains poorly understood. Here we show that the core snRNP protein SmB/B’ self-regulates its expression by promo...
ORGANISM(S): Homo sapiens 
2011-02-01 | E-GEOD-26463 | biostudies-arrayexpress
ProteomicsqXL-MS of insulin resistance in C2C12 myotubes
C2C12 myotubes were made insulin resistant with 0.5 mM palmitic acid for 24 h along with non-treated controls and then each group stimulated with or without 100 nM insulin for 30 min (n=4 each). Cells were then cross-linked with 2 mM of tPhoX for a further 30 min in the presence of insulin and the r...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-29 | PXD077371 | Pride
Tmt C2c12 Tphox 
UnknownMagnetic field effects on radical pair reactions: estimation of B1/2 for flavin-tryptophan radical pairs in cryptochromes.
Not available
S-EPMC9811481 | biostudies-literature
ProteomicsNext-generation Serology by Mass Spectrometry:Readout of the SARS-CoV-2 Antibody Repertoire
Methods of antibody detection are used to assess exposure or immunity to a pathogen. Here, we present Ig-MS, a novel serological readout that captures the immunoglobulin (Ig) repertoire at molecular resolution, including entire variable regions in Ig light and heavy chains. Ig-MS uses new advances i...
ORGANISM(S): Homo Sapiens 
2022-09-24 | PXD028627 | panorama
ProteomicsLC-MS/MS analyses of purified virions of influenza A and B viruses, grown in a range of hosts.
LC-MS/MS analyses of purified virions of influenza A and B viruses, grown in a range of hosts. Described in Hutchinson et al. 'Conserved and host-specific features of influenza virion architecture.'
ORGANISM(S): Bos Taurus (ncbitaxon:9913) Canis Familiaris (canine) Influenza Viruses Gallus Gallus (ncbitaxon:9031) 
2014-06-16 | MSV000078740 | MassIVE
ProteomicsLenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells
Krönke J, Udeshi ND, Narla A, Grauman P, Hurst SN, McConkey M, Svinkina T, Heckl D, Comer E, Li X, Ciarlo C, Hartman E, Munshi N, Schenone M, Schreiber SL, Carr SA, Ebert BL. Science 2014, 343, 301-305. doi:10.1126/science.1244851. Lenalidomide is a drug with clinical efficacy in multiple myeloma an...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-01-26 | MSV000079017 | MassIVE
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