Al amyloidosis - OmicsDI

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Unknown (572)
Transcriptomics (511)
Genomics (203)
Proteomics (90)
Metabolomics (17)
Models (1)
Other (1)
Multiomics (1)

Organisms

Homo sapiens (543)
Mus musculus (91)
Allexis (33)
Arabidopsis thaliana (33)
Callinectes sapidus (33)
Saccharomyces cerevisiae (9)
Rattus norvegicus (8)
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Tetrahymena thermophila (4)
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Caenorhabditis elegans (4)
Pseudomonas chlororaphis subsp. aureofaciens 30-84 (3)
Arabidopsis thaliana (3)
Geobacter sulfurreducens PCA (2)
synthetic construct (2)
Mycobacterium tuberculosis (2)
Pseudomonas aeruginosa PAO1 (2)
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Phaeodactylum tricornutum (1)
Entamoeba histolytica (1)
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Mycobacterium tuberculosis H37Rv (1)
Pseudomonas aeruginosa (1)
cellular organisms (1)

Organisms

Homo sapiens (13)
human gut metagenome (3)
Mus musculus (2)
Pongo pygmaeus (1)

Repository

biostudies-arrayexpress (530)
EGA (146)
MassIVE (35)
pride (33)
ENA (30)
MetaboLights (17)
geo (15)
PanoramaPublic (6)
iProX (5)
jPOST (5)
Cell Collective (1)
EVA (1)

Tissue

Heart (9)
Brain (5)
Abdominal adipose tissue (3)
Microglial cell (3)
Blood plasma (2)
Blood serum (2)
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Liver (2)
Astrocyte of the cerebral cortex (1)
Blood cell (1)
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Conjunctiva (1)
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Orbit (1)
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Urine (1)

Disease

Multiple myeloma (11)
Amyloidosis (5)
Immunoglobulin light chain amyloidosis (5)
Normal (4)
Alzheimer's disease (4)
With bone lytic lesion (1)
Multiple myeloma TC3 (1)
Monoclonal gammopathy of undetermined significance (MGUS) (1)
Monoclonal gammopathy of unknown significance (MGUS) (1)
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Myeloma (1)
Giant cell glioblastoma (1)
Cancer cell line pool (1)
Cervical carcinoma (1)
MGUS (1)
Cervical cancer (1)
Neuroblastoma (1)
Amyloidosis (1)
COVID-19 (1)
Cerebral amyloid angiopathy (1)
Gerstmann-Straussler-Scheinker syndrome (1)

Technology Type

Mass Spectrometry (33)
Shotgun proteomics (14)
Mass spectrometry (11)
Illumina HiSeq 2000 (7)
Bottom-up proteomics (7)
Data-dependent acquisition (4)
Gel-based experiment (4)
HDMSE (4)
NMR spectroscopy (3)
Data-independent acquisition (3)
Illumina HiSeq 2000, ILLUMINA (2)
NMR spectroscopy assay (2)
Mass spectrometry imaging (2)
Illumina HiSeq 2500, ILLUMINA, Affymetrix GeneChip Scanner 3000 7g (1)
NextSeq 500, Illumina HiSeq 4000, ILLUMINA (1)
Illumina HiSeq 3000, ILLUMINA (1)
Illumina HiSeq 4000, ILLUMINA (1)
HiSeq X Ten, ILLUMINA (1)
Illumina Genome Analyzer II, Illumina HiSeq 2000, Affymetrix_SNP6 (1)
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Unknown (1)
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Top-down proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (17)
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Agilent 2100 Bioanalyzer (8)
NextSeq 500 (7)
TruSeq Stranded Total RNA Library Prep Kit with Ribo-Zero Gold (Illumina) (3)
GeneChip Instrument System (2)
Affymetrix mouse gene 1.0 ST arrays (2)
Ribo-Zero Gold (Illumina) (2)
Agilent DNA Microarray Scanner (2)
Affymetrix GeneChip Scanner 3000 (2)
Chemostat (2)
STAR (1)
Single Cell/Low Input RNA Library Prep Kit for Illumina (#E6420S, New England Biolabs) (1)
RNA Micro Kit (Qiagen). (1)
MA900, Sony (1)
10x Chromium Controller (1)
MACS (1)
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454 GS Junior (1)
IScan Illumina (1)
Gene Titan (1)
454 GS FLX+ (1)
Illumina HiScanSQ (1)
ScanArray 5000 [PerkinElmer] (1)
Illumina Genome Analyzer IIx (1)
Axon- GenePix4000B (1)
418 [Affymetrix] (1)
GenePix 4000B [Axon Instruments] (1)
Scanning hardware (1)

Publication Date

2014 (62)
2010 (61)
2015 (55)
2013 (55)
2011 (51)
2012 (50)
2008 (40)
2023 (35)
2016 (34)
2009 (26)
2017 (23)
2025 (22)
2022 (21)
2021 (19)
2007 (18)
2026 (14)
2020 (13)
2019 (13)
2024 (11)
2018 (7)
2006 (3)
2005 (3)
2004 (3)

CHEBI ID

CHEBI:6650 (5)
CHEBI:15354 (5)
CHEBI:30769 (5)
CHEBI:18066 (4)
CHEBI:30751 (4)
CHEBI:15428 (4)
CHEBI:28044 (4)
CHEBI:16704 (4)
CHEBI:16857 (4)
CHEBI:15366 (4)
CHEBI:18012 (4)
CHEBI:16414 (4)
CHEBI:15603 (4)
CHEBI:17895 (4)
CHEBI:17295 (4)
CHEBI:17368 (4)
CHEBI:16024 (3)
CHEBI:16543 (3)
CHEBI:22653 (3)
CHEBI:18186 (3)
CHEBI:28757 (3)
CHEBI:26986 (3)
CHEBI:17234 (3)
CHEBI:28300 (3)
CHEBI:16977 (3)
CHEBI:24898 (3)
CHEBI:15824 (3)
CHEBI:1148 (3)
CHEBI:18123 (3)
CHEBI:27266 (3)

Metabolite Name

Citric acid (5)
Hypoxanthine (5)
Fumaric acid (4)
Malic acid (4)
Phenylalanine (4)
Myrsinone (3)
Phosphoric acid (3)
Leucine (3)
Methylsuccinic acid (3)
Formate (3)
Glycine (3)
Uracil (3)
Succinic acid (3)
L-Threonine (3)
Acetylcholine (3)
Choline (3)
Arachidonic acid (3)
Isocitric acid (3)
Tyrosine (3)
Threonine (3)
Isoleucine (3)
Xanthine (3)
Trehalose (3)
Creatinine (3)
Creatine (3)
L-Valine (3)
Hippuric acid (3)
Diphenyl phosphate (2)
N-Acetyl-L-arginine (2)
Difloxacin (2)

First Public Date

2024 (10)
2026 (4)
2025 (4)
2023 (4)
2022 (2)
2021 (2)
2020 (1)
2019 (1)
2017 (1)
2014 (1)

Modification

4-tetrahydrothiazine-3-carboxylic acid (1)

Study type

Transcription profiling by array (342)
RNA-seq of coding RNA (41)
Comparative genomic hybridization by array (30)
ChIP-seq (18)
RNA-seq of non coding RNA (12)
Genotyping by array (10)
Methylation profiling by array (9)
RNA-seq of coding RNA from single cells (9)
ChIP-chip by tiling array (6)
Transcription profiling by RT-PCR (6)
Other (5)
MicroRNA profiling by array (5)
DNA-seq (5)
Proteomic profiling by array (5)
RNA-seq of total RNA (5)
Unknown experiment type (3)
Cell line - High-throughput sequencing (2)
Transcription profiling by tiling array (2)
Transcription profiling by SAGE (1)
Human - Methylation microarray (1)
Human - Single-cell sequencing (1)
RNAi profiling by array (1)
ChIP-chip by array (1)
CLIP-seq (1)
Antigen profiling (1)
MicroRNA profiling by high throughput sequencing (1)
Spatial transcriptomics by high-throughput sequencing (1)
Bisulfite-seq (1)
ATAC-seq (1)
RIP-seq (1)

Release Date

2025 (91)
2023 (81)
2021 (80)
2022 (79)
2014 (69)
2010 (66)
2015 (62)
2013 (61)
2024 (60)
2012 (55)
2020 (54)
2011 (54)
2016 (48)
2017 (45)
2008 (44)
2019 (43)
2018 (33)
2009 (32)
2007 (19)
2026 (15)
2006 (4)
2005 (3)
2004 (3)
2002 (1)

Lab affiliation

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China (3)
CRIBL Unit, UMR CNRS 7276 INSERM 1262, University of Limoges (2)
Department of Chemistry & Chemical Biology, Northeastern University (2)
Fondazione IRCCS Policlinico San Matteo (2)
Amyloidosis Treatment and Research Center, Fondazione IRCCS Policlinico San Matteo (1)
Amyloidosis Treatment and Research Center, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Italy (1)
Biochemistry and Molecular Biology, Indiana University School of Medicine (1)
Chair of Proteomics and Bioanalytics, Technical University of Munich (TUM), Freising, Germany (1)
DZNE Munich, Neuroproteomics, Feodor-Lynen Str. 17, 81377 Munich, Germany (1)
Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil (1)
Department of Chemistry & Chemical Biology, Northeastern University, Boston, MA, USA (1)
Department of Medicine II, Hematology/Oncology, Goethe University, Frankfurt, Germany. German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany. (1)
Department of Molecular Biology and Genetics, Aarhus University, Denmark (1)
Department of Molecular Medicine, University of Pavia, Pavia, Italy Amyloidosis Research and Treatment Center, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy (1)
Department of Neuroscience, School of Medicine, University of Florida (1)
Department of Pathology, Christian-Albrechts-Universität, Germany (1)
Laboratory of Pediatrics, UMCG, The Netherlands (1)
Mass Spectrometry for Biology Unit, CNRS USR2000, Institut Pasteur, CNRS, 28 rue du Dr Roux, 75015 Paris, France (1)
Mayo Clinic, Rochester, MN (1)
Northeastern University (1)
Oncoprot Platform, TBM-Core US 005, F-33000 Bordeau, France. univ. Bordeaux, Inserm UMR1312 BoRdeaux Institute of onCology (BRIC), F-33000 Bordeaux, France (1)
Program in Molecular and Integrative Physiological Sciences Harvard School of Public Health 665 Huntington Avenue Building 2, Room 221 Boston, MA 02115 USA (1)
Roskamp Institute, Neurodegenerative Disease and Proteomics Lab, Sarasota, FL (1)
University of California San Francisco (1)
University of Oslo, www.pahnkelab.eu (1)
University of Pavia (1)
University of Pavia, Dept. of Molecular Medicine (1)
Wolfson Drug Discovery Unit Centre for Amyloidosis & Acute Phase Proteins Division of Medicine, Royal Free Campus University College London (1)

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Phenotypic, transcriptomic and genomic characterization of clonal plasma cells in light chain amyloidosis [Copy number analysis]

Immunoglobulin light-chain amyloidosis (AL) is a rare clonal plasma cell (PC) disorder that remains largely incurable. AL and multiple myeloma (MM) share the same cellular origin, but while knowledge about MM PC biology has improved significantly, the same does not apply for AL. Here, we undertook a...

ORGANISM(S): Homo sapiens

2016-07-22 | E-GEOD-73041 | biostudies-arrayexpress

Phenotypic, transcriptomic and genomic characterization of clonal plasma cells in light chain amyloidosis [Gene expression profiling]

ORGANISM(S): Homo sapiens

2016-07-22 | E-GEOD-73040 | biostudies-arrayexpress

Clonal plasma cells in AL amyloidosis are dependent on pro-survival BCL-2 family proteins and sensitive to BH3 mimetics alone and in combination with front-line therapies

Amyloid light chain amyloidosis (AL) is an incurable protein misfolding disorder characterized by the production of amyloidogenic immunoglobulin light chains by clonal populations of plasma cells. These abnormal light chains accumulate as amyloid fibrils in vital organs and cause multi-organ dysfunc...

ORGANISM(S): Homo sapiens (Human)

2022-10-03 | PXD024119 | Pride

Al amyloidosis bcl-2 apoptosis bh3 bortezomib proteasome inhibition

Phenotypic, transcriptomic and genomic characterization of clonal plasma cells in light chain amyloidosis

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Homo sapiens

2016-07-22 | E-GEOD-73042 | biostudies-arrayexpress

A mouse model of cardiac AL amyloidosis unveils mechanisms of tissue accumulation and toxicity of amyloid fibrils

ORGANISM(S): Mus musculus (Mouse)

2025-01-17 | PXD059046 | Pride