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TranscriptomicsIMPACT OF INTERLEUKIN 10 DEFICIENCY ON INTESTINAL EPITHELIUM RESPONSES TO INFLAMMATORY SIGNALS
Interleukin-10 (IL-10) is a pleiotropic, anti-inflammatory cytokine that has a major protective role in the intestine. Although its production by cells of the innate and adaptive immune system have been extensively studied, its intrinsic role in intestinal epithelial cells is poorly understood. In t...
ORGANISM(S): Mus musculus 
2021-12-30 | E-MTAB-10217 | biostudies-arrayexpress
TranscriptomicsEffects of human RelA transgene on murine macrophage inflammatory responses
The NFκB family of transcription factors is a major regulator of the innate immune responses, and its dysregulation has been linked to several inflammatory diseases. In this study we focused on bone marrow derived macrophages from the recently described p65-DsRed/IκBα-eGFP transgenic strain, in whic...
ORGANISM(S): Mus musculus 
2022-03-22 | E-MTAB-11461 | biostudies-arrayexpress
TranscriptomicsRNA-seq of PBMC derived macrophages derived from healthy donors in response to lipid A or TNF alpha (Dataset_170630_SysmedIBD_RNA_HEngland)
This aim of this study is to understand changes in gene expression in PBMC-derived macrophages (from healthy individuals) in response to lipid A or TNF alpha stimulation
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-6607 | biostudies-arrayexpress
TranscriptomicsNfkb2 deficiency and its impact on the murine small intestinal mucosa
The alternative (non-canonical) nuclear factor-kappa B (NF-κB) signalling pathway predominantly regulates the function of the p52/RelB heterodimer. Germline Nfkb2 deficiency in mice leads to loss of p100/p52 protein and offers protection against a variety of gastrointestinal conditions, such as azox...
ORGANISM(S): Mus musculus 
2022-07-31 | E-MTAB-11018 | biostudies-arrayexpress
TranscriptomicsRNAtag-Seq data generated from 22 host-relevant conditions in Campylobacter jejuni
RNAtag-Seq were used to investigate the transcriptomic landscape of C. jejuni under 22 growth and stress conditions, with 3 replicates from each condition. 5 extra repeats were created to replaces low-quality samples.
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 
2022-05-27 | E-MTAB-11309 | biostudies-arrayexpress
TranscriptomicsCappable-seq data for discovering condition-specific primary transcriptome in Campylobacter jejuni
The transcription start sites of the Campylobacter jejuni genome was identified by Cappable-seq, which captures primary transcripts by capping the 5´ triphosphorylated end
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 
2022-05-27 | E-MTAB-11308 | biostudies-arrayexpress
ProteomicsThe Cryptosporidium signaling kinase CDPK5 plays an important role in male gametogenesis and parasite virulence
The protozoan parasite Cryptosporidium is a leading cause of diarrhea associated mortality in young children. The parasite’s lifecycle involves a highly coordinated and timely progression from asexual proliferative to sexual stages leading to formation of the transmissible oocyst. Underlying molecul...
ORGANISM(S): Cellular Organisms 
2024-06-04 | PXD051082 | JPOST Repository
UnknownThe return of metabolism: biochemistry and physiology of the pentose phosphate pathway.
Not available
S-EPMC4470864 | biostudies-literature
MetabolomicsPhospholipid acyl chain diversity controls the tissue-specific assembly of mitochondrial cardiolipins

Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for many core tasks of this organelle. Its side chain configurations are tissue-specific, functionally important and generated via post-biosynthetic remodeling. However, this process lacks the necessary specificit...

2020-05-22 | MTBLS1446 | MetaboLights
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