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TranscriptomicsTrivalent Inactivated Influenza Vaccine (TIV) and Live Attenuated Influenza Vaccine (LAIV) Induce Different B cell and Transcriptional Responses in Children
LAIV and TIV are effective for prevention of influenza infection in children, but the mechanisms associated with protection are still not well defined. We analyzed the differences in B cell responses and transcriptional profiles. Compared to baseline, LAIV elicited a significant increase in naM-CM-/...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-52005 | biostudies-arrayexpress
TranscriptomicsResponse of IRF7-deficient peripheral blood mononuclear cells to pH1N1 influenza virus infection
IRF7 plays a critical role in the production and amplification of the antiviral type I and III interferon response. Autosomal recessive IRF7-deficiency resulted in life-threatening influenza disease in a 3-year-old child. We studied the impact of IRF7-deficiency in non-hematopoietic tissues (fibrobl...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-66486 | biostudies-arrayexpress
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