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TranscriptomicsGene expression in rectal epithelia of cystic fibrosis patients
Gene expression profiles were recorded from rectal suction specimens of Cystic Fibrosis (CF) patients, carrying the CF-specific D508 mutated CFTR-allele. These profiles were compared with gene expression profiles from rectal suction specimens of non-CF subjects (control). We used Affymetrix GeneChi...
ORGANISM(S): Homo sapiens 
2013-11-28 | E-GEOD-15568 | biostudies-arrayexpress
TranscriptomicsAnalysis of the Pseudomonas aeruginosa regulon controlled by the sensor kinase KinB and sigma factor RpoN
Alginate overproduction by P. aeruginosa, also known as mucoidy is associated with chronic endobronchial infections in cystic fibrosis (CF). Alginate biosynthesis in this bacterium is initiated by the extracytoplasmic function sigma factor (σ22, AlgU/T). In the wild type (wt) nonmucoid strains, su...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2012-03-01 | E-GEOD-35248 | biostudies-arrayexpress
UnknownCharacterization of novel CSF Tau and ptau biomarkers for Alzheimer's disease.
Not available
S-EPMC3792042 | biostudies-literature
TranscriptomicsExpression data from early diphyodont morphogenesis in minature pig
The miniature pig is diphyodont, making it a valuable alternative model for understanding human tooth development and replacement. However, little is known about gene expression and function during swine odontogenesis. The goal of this study is to undertake the survey of differential gene expressio...
ORGANISM(S): Sus scrofa 
2014-12-23 | E-GEOD-53182 | biostudies-arrayexpress
TranscriptomicsAffymetrix data for training of Endopredict algorithm
These data, combined with other cohorts (GSE6532, GSE12093, and qRT-PCR based cohorts), was used to construct the EP algorithm, which predicts the likelihood of developing of a distant recurrence of early stage breast cancer under endocrine treatment. In addition, EPclin, a combination of the EP sco...
ORGANISM(S): Homo sapiens 
2011-10-10 | E-GEOD-26971 | biostudies-arrayexpress
UnknownTargeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents.
Not available
S-EPMC4789663 | biostudies-literature
UnknownRobust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.
Not available
S-EPMC4931879 | biostudies-literature
TranscriptomicsThe response of PBMCs and primary airway epithelial cells to Influenza and RSV virus
This SuperSeries is composed of the following subset Series: GSE32137: The response of murine primary airway epithelial cells to Influenza infection and the importance of Interferon type I signaling in this response [mAEC]. GSE32138: The response of human primary airway epithelial cells to Influenza...
ORGANISM(S): Homo sapiens 
2012-03-12 | E-GEOD-32140 | biostudies-arrayexpress
TranscriptomicsTranscript profiling of Lymphangioleiomyomatosis (LAM) nodules in Human Patients
Lymphangioleiomyomatosis (LAM) is characterized by cystic lung destruction caused by smooth, muscle-like LAM cells which have mutations in the tumor suppressor genes Tuberous Sclerosis Complex (TSC) 1 or 2, and the capacity to metastasize. Since chemokines and their receptors function in chemotaxis ...
ORGANISM(S): Homo sapiens 
2008-12-30 | E-GEOD-12027 | biostudies-arrayexpress
UnknownIdentification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies.
Not available
S-EPMC9424863 | biostudies-literature
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