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TranscriptomicsEvaluation of DNA-binding preferences of C2H2 zinc finger domains by PBM
The largest and most diverse class of eukaryotic transcription factors contain Cys2-His2 zinc fingers (C2H2-ZFs), each of which typically binds a DNA nucleotide triplet within a larger binding site. Frequent recombination and diversification of their DNA-contacting residues suggests that these zinc...
ORGANISM(S): synthetic construct 
2015-02-17 | E-GEOD-52520 | biostudies-arrayexpress
TranscriptomicsLarge-scale characterization of DNA binding landscape of eukaryotic C2H2 zinc fingers
This SuperSeries is composed of the SubSeries listed below. Cys2-His2 zinc finger (C2H2-ZF) proteins represent the largest class of putative human transcription factors (TFs). However, it is unknown whether most C2H2-ZFs even bind DNA, or what sequences they bind. Using a combination of bacterial...
ORGANISM(S): synthetic construct 
2015-02-17 | E-GEOD-52523 | biostudies-arrayexpress
TranscriptomicsMapping and Analysis of Caenorhabditis elegans Transcription Factor Binding Specificities
The nematode Caenorhabditis elegans is a powerful model for studying gene regulation, as it has a compact genome and a wealth of genomic tools. However, identification of regulatory elements has been hampered by the fact that DNA binding motifs are known for only 71 (9%) of the estimated 763 hi...
ORGANISM(S): synthetic construct 
2015-04-23 | E-GEOD-65719 | biostudies-arrayexpress
TranscriptomicsDetermination and Inference of Eukaryotic Transcription Factor Sequence Specificity
The DNA sequence preferences of the vast majority of eukaryotic transcription factors (TFs) are unknown. Using an approach designed to broadly sample both DNA-binding domain types and eukaryotic clades, we have determined DNA-binding motifs for 1,033 TFs from 131 diverse eukaryotes, encompassing 54...
ORGANISM(S): synthetic construct 
2014-08-01 | E-GEOD-53348 | biostudies-arrayexpress
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