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Transcriptomicssingle cell RNA sequencing of 120h mouse gastruloids cultured with different doses of retinol
We quantified the effects of retinol on the cell type composition of gastruloids at 120 hours after aggregation by single cell RNA sequencing (scRNA-seq). Gastruloids were generated from the Rarb2.LacZ reporter cell line and cultured according to the standard protocol and few modifications: - cultu...
ORGANISM(S): Mus musculus 
2026-07-24 | E-MTAB-17398 | biostudies-arrayexpress
TranscriptomicsTime-lapse RNA sequencing during gastruloid development at different concentrations of retinol
To investigate the effect of retinol on dynamic gene expression patterns during gastruloid development at different doses of retinol, we performed time-lapse bulk RNAseq during gastruloid formation. This allowed us to extract genes that have a dynamic behavior in terms of time, but also in terms of ...
ORGANISM(S): Mus musculus 
2026-07-19 | E-MTAB-15527 | biostudies-arrayexpress
TranscriptomicsSingle cell RNAseq analysis of anti-Vaccinia long-lived memory B cells (CEL-seq2)
Memory B cells represent one of the pillar of humoral protection and are found in the circulation and secondary lymphoid organs several decades after initial pathogen or vaccine encounter. The exact cellular and biological mechanisms allowing long-term survival of quiescent cells in such a fluctuati...
ORGANISM(S): Homo sapiens 
2022-09-19 | E-MTAB-11626 | biostudies-arrayexpress
TranscriptomicsImpact of Hells loss-of-function on DNA methylation in B cells during humoral immune responses: kinetic comparison of Mb1-Hells knockout and control mice by single-cell RNA sequencing
We are interested in deciphering the mechanism by which DNA methylation in late B cell differentiation affects humoral immune response. We chose to study a very rare immunodeficiency called ICF type 4, where a point mutation in a gene encoding the protein HELLS causes a lack of both circulating anti...
ORGANISM(S): Mus musculus 
2023-07-25 | E-MTAB-12499 | biostudies-arrayexpress
TranscriptomicsScRNA-seq analysis of naive, germinal center and memory B cells of mice immunized with homologous and heterologous prime:boost combinations of whole-cell pertussis or acellular pertussis vaccines
Since the introduction of new generation pertussis vaccines, resurgence of pertussis is observed in many developed countries. Former whole-cell pertussis vaccines (wP) are able to protect against disease and transmission but have been replaced in several industrialized countries because of their rea...
ORGANISM(S): Mus musculus 
2022-09-12 | E-MTAB-12156 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of BrO, DMGO and GD2 CAR T cells
Diffuse midline glioma (DMG) is a lethal pediatric brain cancer with limited treatment options. We developed a human brainstem organoid model to study H3.3K27M-driven DMG, enabling formation of patient-like tumors with molecular heterogeneity. To characterize this model, we performed a time-course t...
ORGANISM(S): Homo sapiens 
2025-08-28 | E-MTAB-15147 | biostudies-arrayexpress
UnknownGlobal Retinoblastoma Presentation and Analysis by National Income Level.
Not available
S-EPMC7047856 | biostudies-literature
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