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UnknownChemistry and Pharmacological Actions of Delphinidin, a Dietary Purple Pigment in Anthocyanidin and Anthocyanin Forms.
Anthocyanins are naturally occurring water-soluble flavonoids abundantly present in fruits and vegetables. They are polymethoxyderivatives of 2-phenyl-benzopyrylium or flavylium salts. Delphinidin (Dp) is a purple-colored plant pigment, which occurs in a variety of berries, eggplant, roselle, and wi...
S-EPMC8969030 | biostudies-literature
UnknownQuantum chemical modeling, molecular docking, and ADMET evaluation of imidazole phenothiazine hybrids.
Cancer is one of the biggest challenges for health concerns in the world. There are so many drugs available, but they have a lack of specificity, poor safety, side effects, and the development of resistance. Therefore, there is an urgent need for much safer and more targeted anticancer treatments. N...
S-EPMC12223006 | biostudies-literature
UnknownMorphological Characterization and DNA Barcoding of Duckweed Species in Saudi Arabia.
Duckweeds, or Lemnaceae, are widespread aquatic plants. Morphology-based identification of duckweed species is difficult because of their structural complexity. Hence, molecular tools provide significant advantages for characterizing and selecting species or clones for sustainable commercial use. In...
S-EPMC8620982 | biostudies-literature
UnknownSynthesis and Biological Evaluation of 1,2,3-Triazole Tethered Thymol-1,3,4-Oxadiazole Derivatives as Anticancer and Antimicrobial Agents.
A library of 1,2,3-triazole-incorporated thymol-1,3,4-oxadiazole derivatives (6-18) hasbeen synthesized and tested for anticancer and antimicrobial activities. Compounds 7, 8, 9, 10, and 11 exhibited significant antiproliferative activity. Among these...
S-EPMC8468421 | biostudies-literature
UnknownNew Natural Eugenol Derivatives as Antiproliferative Agents: Synthesis, Biological Evaluation, and Computational Studies.
Semisynthetic modifications of natural products have bestowed us with many anticancer drugs. In the present work, a natural product, eugenol, has been modified synthetically to generate new anticancer agents. The final compounds were structurally confirmed by NMR, IR, and mass techniques. From the c...
S-EPMC10233844 | biostudies-literature
UnknownPotent EGFR/PARP-1 inhibition by spirooxindole-triazole hybrids for targeted liver cancer therapy.
The search for effective anti-cancer therapies has led to the exploration of dual inhibition strategies targeting multiple key molecular pathways. In this study, we aimed to design a novel candidate capable of dual inhibition targeting both EGFR (Epidermal Growth Factor Receptor) and PARP-1 (poly(AD...
S-EPMC11701428 | biostudies-literature
UnknownHPLC and FTIR analysis of phytochemicals and antioxidants of Aloe vera exposed to petroleum hydrocarbons and remediation treatments with organic and inorganic amendments.
Environmental pollution has become a major threat to public safety, and the integrity of bioactive compounds in medical plants. This investigation was conducted to assess the consequence of petroleum hydrocarbons contamination, on the nutritional and medicinal qualities of Aloe vera (L.), and to eva...
S-EPMC12935253 | biostudies-literature
UnknownMapping artificial intelligence adoption in hepatology practice and research: challenges and opportunities in MENA region.

Background

Artificial intelligence (AI) is increasingly relevant to hepatology, yet real-world adoption in the Middle East and North Africa (MENA) is uncertain. We assessed awareness, use, perceived value, barriers, and policy priorities among hepatology clinicians in the region.

Methods<...

S-EPMC12463891 | biostudies-literature
UnknownGlobal economic burden of unmet surgical need for appendicitis.

Background

There is a substantial gap in provision of adequate surgical care in many low- and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis.

Methods

Data on the incidence of appendicitis from 1...
S-EPMC10364778 | biostudies-literature
UnknownUse of Telemedicine for Postdischarge Assessment of the Surgical Wound: International Cohort Study, and Systematic Review With Meta-analysis.

Objective

This study aimed to determine whether remote wound reviews using telemedicine can be safely upscaled, and if standardized assessment tools are needed.

Background

Surgical site infection (SSI) is the most common complication of surgery worldwide, and frequently occurs after h...
S-EPMC10174106 | biostudies-literature
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