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MetabolomicsAtractylodin targets ASAH3L to regulate galactose metabolism and thereby modulates the HIF-1 signaling pathway for the treatment of acute lung injury

Acute lung injury (ALI) is a lung disease characterized by an excessive inflammatory response and damage to lung epithelial cells. Atractylodin (ATL) is the main active component of Atractylodes lancea (Thunb.) DC., which has good anti-inflammatory activity and protects the integrity of the epith...

2024-07-23 | MTBLS9948 | MetaboLights
MetabolomicsBALF Control vs ALI by RPLC-MS
Not available
ORGANISM(S): Homo sapiens 
ST000042 | MetabolomicsWorkbench
TranscriptomicsRNA-seq of In vitro differentiation of ciliated cells in ALI-cultured human airway epithelium
The aim of this study was to analyze gene expression of primary airway epithelial cells during their differentiation in air-liquid interface ALI culture. Cells from one healthy donor were collected at different days of ALI culture (0,6,9,14 and 21). All samples were sequenced on Illumina NovaSeq600...
ORGANISM(S): Homo sapiens 
2021-11-29 | E-MTAB-11209 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human airway epithelial cells sampled at multiple time points to examine mucociliary differentiation
Microarray analysis was performed to identify transcriptional changes that occur during mucociliary differentiation of human primary bronchial epithelial cells cultured at an air-liquid interface (ALI). Experiment Overall Design: Cells from three different donors were cultured and collected at 11 di...
ORGANISM(S): Homo sapiens 
2007-11-11 | E-GEOD-5264 | biostudies-arrayexpress
GenomicsMitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite [CUT&Run]
Mitochondrial L-2-hydroxyglutarate is a physiologic signaling metabolite [CUT&Run]
PRJNA1363940 | ENA
TranscriptomicsAcute Lung Injury In Experimental Malaria
Although respiratory distress is a common complication of severe malaria, little is known about the underlying molecular basis of lung dysfunction. Animal models have provided powerful insights into the pathogenesis of severe malaria syndromes such as cerebral malaria; however, no model of malaria-i...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-9497 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-seq of isolated human foetal L/M-opsin cone photoreceptor populations labelled using the AAV2/9.pR2.1.GFP reporter
Human cone photoreceptors represent a rare cell population of the human retina and are largely outnumbered by other retinal cell types. Despite their rarity, cone photoreceptors are critical for optimal daylight vision and their loss has the greatest impact on sight during the progression of retinal...
ORGANISM(S): Homo sapiens 
2018-04-20 | E-MTAB-6058 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression erofiling of an in vitro model for studying esophageal epithelial differentiation
We used RNA sequencing to identify differentially expressed genes during esophageal epithelial differentiation and in the presence of interleukin 13 using an air-liquid interface culture system. RNA sequencing was performed on a human esophageal epithelial cell line (EPC2-hTERT) grown submerged (day...
ORGANISM(S): Homo sapiens 
2015-02-01 | E-GEOD-65335 | biostudies-arrayexpress
ProteomicsHuman CCDC114-mutant patient derived air-liquid interface (ALI) organoids proteome
In this experiment we investigate the different expressed proteins between healthy control ALI organoids and CCDC114-mutant ALI organoids.
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD064456 | Pride
Human Organoids Airway Ccdc114 
TranscriptomicsDo Airway Epithelium Air-liquid Cultures Represent the In Vivo Airway Epithelium Transcriptome?
Human airway epithelial cells cultured in vitro at air-liquid interface (ALI) form a pseudostratified epithelium that forms tight junctions and cilia, and produces mucin, and are widely used as a model of differentiation, injury, and repair. To assess how closely the transcriptome of ALI epithelium ...
ORGANISM(S): Homo sapiens 
2010-07-07 | E-GEOD-18637 | biostudies-arrayexpress
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