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TranscriptomicsDiffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. We proposed that this variability in natural history refle...
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-60 | biostudies-arrayexpress
TranscriptomicsDNA copy-number changes
Gene amplifications and deletions frequently contribute to tumorigenesis. Characterization of these DNA copy-number changes is important for both the basic understanding of cancer and its diagnosis. Comparative genomic hybridization (CGH) was developed to survey DNA copy-number variations across a w...
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-49 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Jurkat T cell line and mouse thymocytes
Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and negative regulators establishes such a tonic signal. Ligandindependent signaling by the precursors of mature...
ORGANISM(S): Homo sapiens 
2005-10-14 | E-SMDB-2194 | biostudies-arrayexpress
TranscriptomicsAdult T-cell leukemia-lymphoma and AZT-IFNa combination therapy
Adult T-cell leukemia-lymphoma (ATLL) is an HTLV-1-associated lymphoproliferative malignancy that is frequently fatal. We compared gene expression profiles (GEPs) of leukemic specimens from 9 patients with ATLL at the time of diagnosis and immediately after combination therapy with zidovudine (AZT) ...
ORGANISM(S): Homo sapiens 
2010-04-12 | E-GEOD-19160 | biostudies-arrayexpress
TranscriptomicsLymphomaTransformation
Transformation of Follicular Lymphoma to Diffuse Large Cell Lymphoma: Alternative Patterns with Increased or Decreased Expression of c-myc and its Regulated genes The natural history of follicular lymphoma (FL) is frequently characterized by transformation to a more aggressive diffuse large ...
ORGANISM(S): Homo sapiens 
2005-10-18 | E-GEOD-3458 | biostudies-arrayexpress
TranscriptomicsHGAL Enhances BCR-mediated Syk Activation, Leading to Lymphoid Hyperplasia and Amyloidosis
Gene expression data from CD22+B220+ FACS-purified splenocytes of adult Sca1-HGAL knock-in CBAxC57BL/6J mice or wild-type littermates. Transgenic mice expressing HGAL (GCET2) under control of the Sca1 (Ly-6E.1) promoter were generated. CD22 and B220 dual-positive B-cells were FACS purified from sple...
ORGANISM(S): Mus musculus 
2013-05-22 | E-GEOD-35400 | biostudies-arrayexpress
UnknownA simple and exact Laplacian clustering of complex networking phenomena: application to gene expression profiles.
Not available
S-EPMC2393820 | biostudies-literature
TranscriptomicsRelation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia
The most common human leukemia is B cell chronic lymphocytic leukemia (CLL), a malignancy of mature B cells with a characteristic clinical presentation but a variable clinical course. The rearranged immunoglobulin (Ig) genes of CLL cells may be either germ-line in sequence or somatically mutated. La...
ORGANISM(S): Homo sapiens 
2005-08-27 | E-GEOD-3211 | biostudies-arrayexpress
GenomicsClonal Evolution of Pre-Leukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia

Acute myeloid leukemia is an aggressive clonal malignancy of the bone marrow that is the direct result of sequential acquisition of mutations in a single lineage of cells. In this study, we investigate a model in which this mutational acquisition occurs serially in long-lived self-renewing hemato...

phs000549.v1.p1 | EGA
TranscriptomicsTranscription profiling of follicular lymphoma to diffuse large cell lymphoma
Transformation of Follicular Lymphoma to Diffuse Large Cell Lymphoma: Alternative Patterns with Increased or Decreased Expression of c-myc and its Regulated genes The natural history of follicular lymphoma (FL) is frequently characterized by transformation to a more aggressive diffuse large ...
ORGANISM(S): Homo sapiens 
2005-09-23 | E-SMDB-963 | biostudies-arrayexpress
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