Sort   by:  
 Page size 
ProteomicsThe role and cooperation of AidB dehydrogenase and AlkB dioxygenase in repair of adducts to DNA and RNA bases
The aim of the project is to conduct in vivo, in vitro and in silico studies of the substrate specificity of AidB dehydrogenase against the by-products rising in AlkB dioxygenase repair reaction and AlkB and AidB cooperative interaction in the repair of adducts to DNA and RNA bases. AidB dehydrogena...
ORGANISM(S): Escherichia coli 
2025-05-07 | PXD057294 | Pride
Aidb dehydrogenase Dna repair Alkb dioxygenase E.coli Rna repair 
TranscriptomicsTestis samples from Alkbh1 wild-type and KO mice
The aim of the study was to elucidate the role of Alkbh1 by targeted deletion in C57/BL6 mice. Alkb deficiency results in sex-ratio distortion of offspring and apoptosis in adult testes, most likely caused by defects in the pachytene stage during spermatogenesis. Due to the pivotal role of Alkbh1 in...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-22073 | biostudies-arrayexpress
TranscriptomicsThe human AlkB homologue 4 interacts with proteins associated with transcription (expression)
The Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from E. coli is a demethylase which repairs alkyl lesions in DNA, as well as RNA, through a direct reversal mechanism. Humans possess nine AlkB homologues (ALKBH1-8 and FTO). ALKBH2 and ALKBH3 display demethylase activities correspondin...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-39127 | biostudies-arrayexpress
TranscriptomicsThe human AlkB homologue 4 interacts with proteins associated with transcription (methylation)
The Fe(II)- and 2-oxoglutarate (2OG)-dependent dioxygenase AlkB from E. coli is a demethylase which repairs alkyl lesions in DNA, as well as RNA, through a direct reversal mechanism. Humans possess nine AlkB homologues (ALKBH1-8 and FTO). ALKBH2 and ALKBH3 display demethylase activities correspondin...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-39126 | biostudies-arrayexpress
UnknownAlkB dioxygenase preferentially repairs protonated substrates: specificity against exocyclic adducts and molecular mechanism of action.
Not available
S-EPMC3537041 | biostudies-literature
UnknownA Single-Turnover Kinetic Study of DNA Demethylation Catalyzed by Fe(II)/α-Ketoglutarate-Dependent Dioxygenase AlkB.
Not available
S-EPMC6943663 | biostudies-literature
UnknownMechanism of repair of acrolein- and malondialdehyde-derived exocyclic guanine adducts by the α-ketoglutarate/Fe(II) dioxygenase AlkB.
Not available
S-EPMC4164229 | biostudies-literature
UnknownThe role of demethylase AlkB homologs in cancer.
Not available
S-EPMC10060643 | biostudies-literature
UnknownStructural basis for substrate discrimination by E. coli repair enzyme, AlkB.
Not available
S-EPMC9076979 | biostudies-literature
UnknownCrystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification.
Not available
S-EPMC3265892 | biostudies-literature
Sort   by:  
 Page size