HOXA13 Binding sites were located genome wide in primary human foreskin fibroblasts Tiled promoters with a probe per 100bp of refseq known genes 3kb upstream and 700 bp downstream of transcriptional start
HOXA13 was depleted by siRNA mediated technology in Foreskin Fibroblast at 20nM and 100nM siRNA concentration. As a control siGFP was used at 20nM and 100nM for respective gene expression comparisons.
This study is part of the Gene Environment Association Studies initiative (GENEVA) funded by the National Human Genome Research Institute. The overarching goal is to identify novel genetic factors that contribute to addiction through a large-scale genome-wide association study of DSM-IV alcoh...
