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Genes involved in the inflammatory response resulting in allergic contact dermatitis (ACD) are only partly known. In this study, we introduce the use of high density oligonucleotide arrays for gene expression profiling in human skin during the elicitation of ACD. Skin biopsies from normal and nickel...
ORGANISM(S): Homo sapiens 
Molecular analysis in SADBE-induced ACD (Allergic contact dermatitis) model
The mechanisms underlying pruritus of SADBE induced ACD (Allergic contact dermatitis) remain poorly understood,due to limited clinical data and animal studies. In this study, we investigated whether there are certain key signaling molecules downstream of the recently identified peptides mediating it...
ORGANISM(S): Mus musculus 
2023-06-16 | GSE152646 | GEO
Allergic contact dermatitis (ACD) is the most prevalent form of immunotoxicity in humans. Dendritic cells (DC) play a central role in the pathogenesis of ACD, particularly during the sensitization phase to a specific allergen. Upon activation, DCs maturate and migrate to draining lymph nodes which i...
ORGANISM(S): Homo sapiens (Human) 
2021-03-29 | PXD022599 | Pride
Our findings demonstrate that nickel-challenged skin in subjects with allergy to nickel is characterized by a specific miRNA signature compared to vehicle-challenged skin. In addition, we found that miRNA expression changes are different in allergic contact dermatitis (ACD to nickel) compared to irr...
ORGANISM(S): Homo sapiens Mus musculus Rattus norvegicus 
2015-10-01 | GSE58814 | GEO
Distinct immune responses and pruritic mechanisms in oxazolone- and urushiol- induced ACD (Allergic contact dermatitis) models.
Transcriptional Profile in Allergic Contact Dermatitis to Methylisothiazolinone
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