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UnknownICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype.
Not available
S-EPMC10959121 | biostudies-literature
UnknownAnti-CTLA-4 generates greater memory response than anti-PD-1 via TCF-1.
Not available
S-EPMC11745370 | biostudies-literature
TranscriptomicsIn vivo gene expression data from wild type and CTLA-4 KO 5C.C7 T cells
CTLA-4 is thought to inhibit effector T cells both intrinsically, by competing with CD28 for B7 ligands, and extrinsically, through the action of regulatory T cells. We studied in vivo responses of normal and CTLA-4-deficient antigen-specific murine effector CD4+ T cells. In order to do these studie...
ORGANISM(S): Mus musculus 
2012-09-05 | E-GEOD-37563 | biostudies-arrayexpress
UnknownMacrophage-Dendritic Cell-T-Cell Tetrads Orchestrate Antitumor Immunity and Response to Checkpoint Blockade.
Not available
S-EPMC12776307 | biostudies-literature
TranscriptomicsFriends not foes: CTLA-4 blockade and mTOR inhibition cooperate during CD8+ T cell priming
T cells receive numerous positive and negative signals during primary antigen encounter that control their proliferation and function, but how these signals are integrated to modulate T cell memory has not been fully characterized. In these studies, we demonstrate that combining seemingly opposite ...
ORGANISM(S): Mus musculus 
2015-01-31 | E-GEOD-63022 | biostudies-arrayexpress
UnknownCancer-induced nerve injury promotes resistance to anti-PD-1 therapy.
Not available
S-EPMC12406299 | biostudies-literature
GenomicsWTCCC3_Pre-Eclampsia
WTCCC3 UK maternal cases of pre-eclampsia
EGAD00010000854 | EGA
GenomicsInterPregGen-GWAS-UZB-2
GWAS genotype data for maternal and fetal (baby) cases of preeclampsia and controls from Uzbekistan. This dataset is a component of the InterPregGen FP7 project. DNA samples for this component were collected by InterPregGen Consortium members in Tashkent, Uzbekistan at the Institute of Immunology, U...
EGAD00010001917 | EGA
GenomicsInterPregGen-GWAS-KAZ-3
Preeclampsia (PE) is a syndrome affecting pregnant mothers and fetus/babies characterised by hypertension and proteinuria, and is a leading cause of maternal and fetal death and of premature births worldwide. The InterPregGen Consortium was funded by a European Framework 7 (FP7) grant and grew out o...
EGAD00010001949 | EGA
GenomicsPE-META-CENTRAL_ASIA-MATERNAL
Fixed effect meta-analysis summary statistics combining GWAS of maternal preeclampsia cases and controls from Central Asia (Kazakhstan and Uzbekistan).
EGAD00010001985 | EGA
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