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TranscriptomicsExpression profiling of B.subtils SMY wild-type, (p)ppGpp0, M-NM-^TcodY (p)ppGpp0 and guaB- (p)ppGpp0 cells upon amino acid starvation (RHX) or guanosine (Guo) treatment.
The nucleotide (p)ppGpp is crucial for viability during amino acid limitation in bacteria, yet how it accomplishes this remains unknown. We found that the absence of (p)ppGpp in Bacillus subtilis cells leads to multiple amino acid auxotrophy, and that (p)ppGpp allows for prototrophy by reducing GTP ...
ORGANISM(S): Bacillus subtilis subsp. subtilis str. 168 
2013-11-01 | E-GEOD-41501 | biostudies-arrayexpress
UnknownICOS costimulation in combination with CTLA-4 blockade remodels tumor-associated macrophages toward an antitumor phenotype.
Not available
S-EPMC10959121 | biostudies-literature
TranscriptomicsExpression profiling of B.subtils SMY wild-type vs. (p)ppGpp0 cells upon amino acid starvation.
Cells constantly adjust their metabolism in response to environmental conditions, yet major mechanisms underlying survival remain poorly understood. We discover a post-transcriptional mechanism that integrates starvation response with GTP homeostasis to allow survival, enacted by the nucleotide (p)p...
ORGANISM(S): Bacillus subtilis 
2012-11-01 | E-GEOD-39758 | biostudies-arrayexpress
UnknownThe Macromolecular Basis of Phytoplankton C:N:P Under Nitrogen Starvation.
Not available
S-EPMC6479212 | biostudies-literature
UnknownBis(μ-diethyl-phosphido-κP:P)bis-[bis(2,4,6-trimethyl-phen-yl)indium(III)].
Not available
S-EPMC3246993 | biostudies-literature
UnknownLatitudinal patterns in ocean C:N:P reflect phytoplankton acclimation and macromolecular composition.
Not available
S-EPMC11572967 | biostudies-literature
MetabolomicsSoftware tool for internal standard based normalization of lipids, and effect of data-processing strategies on resulting values

BACKGROUND: Lipidomics, the comprehensive measurement of lipids within a biological system or substrate, is an emerging field with significant potential for improving clinical diagnosis and our understanding of health and disease. While lipids diverse biological roles contribute ...

2022-05-17 | MTBLS710 | MetaboLights
TranscriptomicsCHAC1 mRNA expression is a strong prognostic biomarker in breast and ovarian cancer
Extracellular, cancer-specific methylated DNA has been shown to be a prognostic marker when detected in serum or plasma. In this study we investigated the effect of treating cancer cells with differentially methylated CpG DNA. When breast cancer cell lines were treated with methylated CpG DNA, a con...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-22865 | biostudies-arrayexpress
UnknownAnti-CTLA-4 generates greater memory response than anti-PD-1 via TCF-1.
Not available
S-EPMC11745370 | biostudies-literature
MetabolomicsMulti-dimensional leaf phenotypes reflect root system genotype in grafted grapevine over the growing season

BACKGROUND: Modern biological approaches generate volumes of multi-dimensional data, offering unprecedented opportunities to address biological questions previously beyond reach owing to small or subtle effects. A fundamental question in plant biology is the extent to which below...

2022-01-07 | MTBLS2831 | MetaboLights
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