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ProteomicsMolecular basis of TMED9 oligomerization and entrapment of misfolded protein cargo in the early secretory pathway
Xiao L, Pi X, Goss AC, El-Baba T, Ehrmann JF, Grinkevich E, Bazua-Valenti S, Padovano V, Alper SL, Carey D, Udeshi ND, Carr SA, Pablo JL, Robinson CV, Greka A, Wu H. 2024 Intracellular accumulation of misfolded proteins causes serious human proteinopathies. The transmembrane emp24 domain 9 (TMED9) ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-29 | MSV000089757 | MassIVE
TranscriptomicsExpression data from S. cerevisiae, S288C with graded GCN5 F221A
S288C was transformed with plasmids expressing the GCN5 F221A mutant at varying levels. We sought to examine the global impact on gene expression using the Affymetrix yeast 2.0 arrays. TEF promoter strength varied from 32, 68 and 95% of the wild-type expression. Controls included wild-type with em...
ORGANISM(S): Saccharomyces cerevisiae 
2012-05-02 | E-GEOD-26923 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of LPS-stimulated RAW264.7 macrophages overexpressing Tbc1d23 novel innate immune gene
We previously identified Tbc1d23 as a candidate novel regulator of innate immunity using comparative genomics RNAi screens in C. elegans and mouse macrophages. Using mice with an engineered knockout mutation in Tbc1d23 and macrophages engineered to overexpress Tbc1d23, we now show that Tbc1d23 is a ...
ORGANISM(S): Mus musculus 
2012-04-03 | E-GEOD-30840 | biostudies-arrayexpress
UnknownAPOL1 Kidney Risk Variants Induce Cell Death via Mitochondrial Translocation and Opening of the Mitochondrial Permeability Transition Pore.
Not available
S-EPMC6900802 | biostudies-literature
TranscriptomicsEffect of SF3A1 inhibition on pre-mRNA splicing
We previously found that the SF3A mRNA splicing complex was required for a robust innate immune response; SF3A acts in part by inhibiting the production of a negatively acting splice form of the TLR signaling adaptor MyD88. Here we inhibit SF3A1 using RNAi and subsequently perform an RNAseq study to...
ORGANISM(S): Mus musculus 
2015-02-09 | E-GEOD-58432 | biostudies-arrayexpress
ProteomicsEndo_ASPHvariants_APMS_P124_6600
This dataset consists of 10 raw MS files and associated peak lists and results files, acquired on AB Sciex TripleTOF 6600 mass spectrometer operated in Data Dependent Acquisition mode. Samples were generated by Yukari Endo. Mass spectrometry acquisition and data analysis was performed by Cassandra ...
ORGANISM(S): Danio Rerio (ncbitaxon:7955) Homo Sapiens (ncbitaxon:9606) 
2022-05-04 | MSV000089417 | MassIVE
UnknownDesign and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel K<sub>Ca</sub>3.1.
Not available
S-EPMC12067266 | biostudies-literature
ProteomicsEndothelial pathomechanisms in response to in vitro peritoneal dialysis fluid exposure
Loss of ultrafiltration capacity in peritoneal dialysis (PD) patients is often associated with peritoneal vascular changes, manifest as diabetes-like vasculopathy and angiogenesis. The endothelial monolayer lining the vessel lumen controls vessel barrier function and thereby influences peritoneal su...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022170 | Pride
Human umbilical vein endothelial cells Tmt Dialysis 
ProteomicsEndothelial pathomechanisms in response to in vivo peritoneal dialysis fluid exposure
Loss of ultrafiltration capacity in peritoneal dialysis (PD) patients is often associated with peritoneal vascular changes, manifest as diabetes-like vasculopathy and angiogenesis. The endothelial monolayer lining the vessel lumen controls vessel barrier function and thereby influences peritoneal su...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD022183 | Pride
Tmt Dialysis Human arterioles 
UnknownEffect of Nitric Oxide Pathway Inhibition on the Evolution of Anaphylactic Shock in Animal Models: A Systematic Review.
Not available
S-EPMC9228251 | biostudies-literature
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