Alpha-2-macroglobulin

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Transcriptomics (457)
Unknown (242)
Genomics (81)
Proteomics (45)
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Organisms

Homo sapiens (186)
Mus musculus (141)
Drosophila melanogaster (39)
Arabidopsis thaliana (26)
Saccharomyces cerevisiae (25)
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Vibrio harveyi (9)
Caenorhabditis elegans (9)
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synthetic construct (5)
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Organisms

Mus musculus (3)
Homo sapiens (2)
Rattus norvegicus (1)

Repository

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Breast cancer (1)
Eye disease (1)
Heart failure (1)
Liver disease (1)
Osteoarthritis (1)

Technology Type

Mass Spectrometry (11)
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2010 (92)
2013 (72)
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2007 (22)
2026 (13)
2005 (13)
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2003 (1)

CHEBI ID

CHEBI:75008 (2)
CHEBI:25801 (2)
CHEBI:17768 (2)
CHEBI:75016 (2)
CHEBI:75010 (2)
CHEBI:16543 (2)
CHEBI:18237 (2)
CHEBI:22660 (2)
CHEBI:28300 (2)
CHEBI:73506 (2)
CHEBI:73527 (2)
CHEBI:73912 (2)
CHEBI:141447 (1)
CHEBI:141426 (1)
CHEBI:32401 (1)
CHEBI:73806 (1)
CHEBI:141391 (1)
CHEBI:15405 (1)
CHEBI:141390 (1)
CHEBI:141442 (1)
CHEBI:141407 (1)
CHEBI:141406 (1)
CHEBI:141403 (1)
CHEBI:141412 (1)
CHEBI:89110 (1)
CHEBI:89348 (1)
CHEBI:178211 (1)
CHEBI:178210 (1)
CHEBI:178209 (1)
CHEBI:21780 (1)

Metabolite Name

N-Acetylputrescine (2)
Glutamine (2)
Aspartic acid (2)
Quercetin 3-O-glucoside 7-O-rhamnoside (1)
Kaempferol 3-O-glucoside 7-O-rhamnoside (1)
S-Adenosyl methionine (1)
4-[(2E)-3,7-dimethyl-5-oxoocta-2,6-dienyl]-3-methylideneoxolan-2-one (1)
Pyridoxamine-5'-phosphate (1)
4-hydroxy-4-[(E)-3-hydroxybut-1-enyl]-3,5,5-trimethylcyclohex-2-en-1-one (1)
(2E)-11-Hydroxy-2-dodecenoic acid (1)
N-epsilon,N-epsilon,N-epsilon-Trimethyllysine (1)
Alpha-aminopimelic acid (1)
N-Acetyl-L-ornithine (1)
Fenchyl alcohol (1)
Pyridoxol (1)
L-Methionine methylsulfonium (1)
N-(2-Hydroxyethyl)-beta-alanine (1)
Beta-Hydroxynorvaline (1)
3,4-Dimethylaniline (1)
Gamma-Amino-beta-hydroxybutyric acid (1)
(R)-2-Aminobutanoic acid (1)
2',3'-Cyclic Adenosine monophosphate (1)
Alpha-D-Talose (1)
Oxo proline (1)
Stearic acid (18:0) (1)
Phenyl sulfoxide (1)
Oxo-octadecadienoic acid (1)
Octadecyl-oxy-octadecanoic acid (SAHSA) (1)
Octadecanoyloxamide (1)
Nonadecanoic acid (C19:0) (1)

IsPrivate

False (1)

First Public Date

2023 (3)
2018 (2)
2014 (2)
2024 (1)
2017 (1)
2015 (1)

Study type

Transcription profiling by array (288)
ChIP-seq (60)
RNA-seq of coding RNA (37)
Other (30)
Unknown experiment type (20)
ChIP-chip by tiling array (20)
ChIP-chip by array (18)
RNA-seq of non coding RNA (7)
Transcription profiling by tiling array (5)
MicroRNA profiling by array (5)
Comparative genomic hybridization by array (4)
Proteomic profiling by array (4)
MNase-seq (3)
ATAC-seq (3)
Methylation profiling by array (3)
Methylation profiling by high throughput sequencing (3)
RNAi profiling by array (2)
RNA-seq of total RNA (2)
Transcription profiling by SAGE (1)
One-color microarray (1)
Cell line - High-throughput sequencing (1)
Genotyping by array (1)
DNA-seq (1)
RNA-seq of coding RNA from single cells (1)

Release Date

2010 (100)
2013 (80)
2015 (66)
2012 (47)
2011 (47)
2014 (45)
2009 (43)
2008 (43)
2016 (33)
2021 (29)
2022 (27)
2023 (25)
2020 (25)
2007 (24)
2018 (18)
2017 (17)
2025 (16)
2019 (16)
2005 (16)
2024 (14)
2006 (13)
2026 (10)
2004 (6)
2003 (2)
2000 (2)

Lab affiliation

Neuroimmunology Unit Institute of Experimental Neurology San Raffaele Scientific Institute Via Olgettina 60 Milan 20132, Italy (2)
Beijing University of Agriculture, China (1)
Department of Clinical Sciences, Cornell University, Ithaca, NY, USA Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, CA, USA (1)
Department of Plasma Proteins, Sanquin-AMC Landsteiner Laboratory, Amsterdam, The Netherlands (1)
Escola Superior de Saúde Instituto de Biomedicina - iBiMED Universidade de Aveiro 3810-193 Aveiro Portugal (1)
ICAR- Central Inland Fisheries Research Institute, Fishery Resource and Environmental Management Division, Biochemistry Laboratory, Proteomics Unit, Barrackpore- 700120. Ph- +919230618153 (1)
MBG, Aarhus University, Denmark (1)
SaBio (Health and Biotechnology), Instituto de Investigación en Recursos Cinegéticos (IREC, CSIC-UCLM-JCCM), University of Castilla-La Mancha, 13071, Ciudad Real, Spain. (1)
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD (1)

Tags

xref:PubMed:18446208 (1)
xref:PubMed:22623392 (1)
xref:PubMed:37965574 (1)

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Alpha-2-Macroglobulin in Inflammation, Immunity and Infections.

Not available

S-EPMC8712716 | biostudies-literature

Serum Alpha-2-Macroglobulin Links Type 1 Diabetes Status and Incident Cardiovascular Disease

Background: Cardiovascular disease (CVD) is a leading cause of mortality in individuals with type 1 diabetes mellitus (T1DM), with conventional risk factors not fully explaining the heightened risk. Study Design: We conducted a cross-sectional study comparing serum protein levels in 134 participants...

ORGANISM(S): Homo Sapiens

2025-02-11 | PXD054039 | panorama

Structural Mechanics of the Alpha-2-Macroglobulin Transformation.

Not available

S-EPMC8897276 | biostudies-literature

Homotrimeric MMP-9 is an active hitchhiker on alpha-2-macroglobulin partially escaping protease inhibition and internalization through LRP-1.

Not available

S-EPMC11104829 | biostudies-literature

Novel Role for Alpha-2-Macroglobulin (A2M) as a Disease Modifying Protein in Senile Osteoporosis

PRJNA1018558 | ENA

Structure of protease-cleaved Escherichia coli α-2-macroglobulin reveals a putative mechanism of conformational activation for protease entrapment.

Not available

S-EPMC4498604 | biostudies-literature

Protease-activated alpha-2-macroglobulin can inhibit amyloid formation via two distinct mechanisms.

Not available

S-EPMC3581772 | biostudies-literature

miRNA-99 family diverges physiological cardiac hypertrophy to pathological cardiac hypertrophy

Purpose: The physiological cardiac hypertrophy is an adaptive condition that does not associate with myocyte cell death while pathological hypertrophy is a maladaptive condition associated with myocyte cell death. Alpha-2 macroglobulin (Î±-2M) an acute phase protein induces cardiac hypertrophy via t...

ORGANISM(S): Rattus norvegicus

2015-11-01 | E-GEOD-73597 | biostudies-arrayexpress

MiR-146b accelerates osteoarthritis progression by targeting alpha-2-macroglobulin.

Not available

S-EPMC6738400 | biostudies-literature

Retinal Pigment Epithelium-Secreted VEGF-A Induces Alpha-2-Macroglobulin Expression in Endothelial Cells.

Not available

S-EPMC9564307 | biostudies-literature

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