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TranscriptomicsTranscription profiling of mouse transgenics (3 mo) inducibly expresssing human alpha1-antitrypsin in the liver
In the classical form of α1antitrypsin deficiency a mutant protein accumulates in a polymerized form in the ER of liver cells causing liver damage and carcinogenesis by a gain-of-toxic function mechanism. Recent studies have indicated that the accumulation of mutant α1antitrypsin Z in the ER spec...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8599 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse (6 wk) inducibly expresssing human alpha1-antitrypsin in the liver
In the classical form of α1antitrypsin deficiency a mutant protein accumulates in a polymerized form in the ER of liver cells causing liver damage and carcinogenesis by a gain-of-toxic function mechanism. Recent studies have indicated that the accumulation of mutant α1antitrypsin Z in the ER spec...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-8600 | biostudies-arrayexpress
UnknownCase-finding for alpha1-antitrypsin deficiency in Kazakh patients with COPD.
Not available
S-EPMC5655868 | biostudies-literature
GenomicsMice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin
Mice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin
PRJNA884623 | ENA
GenomicsAlpha1-Antitrypsin Deficiency Registry (AADR-BioLINCC)
Alpha1-Antitrypsin Deficiency Registry (AADR-BioLINCC)
PRJNA1296684 | ENA
GenomicsAlpha1-Antitrypsin Deficiency Registry (AADR-BioLINCC)
Alpha1-Antitrypsin Deficiency Registry (AADR-BioLINCC)
PRJNA1296685 | ENA
TranscriptomicsMice inflammatory responses to inhaled aerosolized LPS: effects of various forms of human alpha1-antitrypsin
Characterize how Balb/c mice responses to aerosolized LPS (lipopolysaccharide) alone or with intraperitoneal (i.p.) delivery of alpha1-antitrypsin (AAT)
ORGANISM(S): Mus musculus 
2022-09-30 | GSE214249 | GEO
UnknownA novel alpha1-antitrypsin null variant (PiQ0Milano ).
Not available
S-EPMC3767846 | biostudies-literature
TranscriptomicsCurative and beta cell regenerative effects of alpha1 antitrypsin treatment in autoimmune diabetic NOD mice
In this study, we performed the gene expression analysis of the Normal, Diabetic and AAT treated NOD mice to elucidate the transcriptional changes induced by AAT. This will assist in identifying the biological processes / pathways involved in curative mechanism of AAT. Keywords: alpha1 antitrypsin t...
ORGANISM(S): Mus musculus 
2008-12-31 | GSE10478 | GEO
GenomicsCandida albicans: control vs. alpha1-antitrypsin (AAT) treatment
Candida albicans: control vs. alpha1-antitrypsin (AAT) treatment
PRJNA694109 | ENA
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