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We analyzed a role of Brd2 protein in transcription and alternative splicing. 289 genes change alternative splicing after Brd2 knockdown and 1459 genes alter gene expression compared to cells treated with negative control siRNA. 6 samples (3 independent samples of cells treated with Brd2 siRNA, 3 sa...
ORGANISM(S): Homo sapiens 
Mammalian development is an intricate process regulated by multiple gene isoforms and their epigenetic states, which are yet undefined. Using integrative massive parallel sequencing and bioinformatics approach, we built genome-wide inventory of transcript variants, their promoters and histone modifi...
ORGANISM(S): Mus musculus 
This SuperSeries is composed of the following subset Series: GSE26877: Nprl3 is Required for Normal Development of the Cardiovascular System GSE27918: Genome-wide maps of chromatin state in mouse erythroid cells. GSE27919: Genome-wide map of DNaseI hypersensitivity in mouse erythroid cells. GSE27920...
ORGANISM(S): Mus musculus 
Systematic Transcriptome Analysis Reveals the Crucial Role of Alternative Promoters in Hematopoietic Lineages
Chromatin-dependent cryptic promoters encode alternative protein isoforms in yeast
Aberrant DNA hypomethylation may play an important role in the growth rate of glioblastoma (GBM), but the functional impact on transcription remains poorly understood. We assayed the GBM methylome with MeDIP-seq and MRE-seq, adjusting for copy number differences, in a small set of non-glioma CpG isl...
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