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ProteomicsPhase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres
RPA has been shown to protect single-stranded DNA (ssDNA) intermediates from instability and breakage. RPA binds ssDNA with sub-nanomolar affinity, yet dynamic turnover is required for downstream ssDNA transactions. How ultrahigh-affinity binding and dynamic turnover are achieved simultaneously is n...
ORGANISM(S): Homo sapiens (Human) 
2023-03-15 | PXD036935 | Pride
Alternative lengthening of telomeres (alt) Replication protein a (rpa) Nuclear organization Biomolecular condensates Genome stability Single-stranded dna (ssdna) 
ProteomicsCharacterization of post-mitotic DNA synthesis and its regulation in human cells
DNA replication stress promotes cancer development and is associated with DNA synthesis beyond S-phase. Replication stress-induced DNA lesions and under-replicated DNA can persist into G2 and mitosis, where they undergo mitotic DNA synthesis (MiDAS). After cell division, inherited DNA lesions are pr...
ORGANISM(S): Homo sapiens (Human) 
2026-08-26 | PXD069592 | Pride
ProteomicsCharacterization of post-mitotic DNA synthesis and its regulation in human cells
DNA replication stress promotes cancer development and is associated with DNA synthesis beyond S-phase. Replication stress-induced DNA lesions and under-replicated DNA can persist into G2 and mitosis, where they undergo mitotic DNA synthesis (MiDAS). After cell division, inherited DNA lesions are pr...
ORGANISM(S): Homo sapiens (Human) 
2026-08-26 | PXD069739 | Pride
ProteomicsCharacterization of post-mitotic DNA synthesis and its regulation in human cells
DNA replication stress promotes cancer development and is associated with DNA synthesis beyond S-phase. Replication stress-induced DNA lesions and under-replicated DNA can persist into G2 and mitosis, where they undergo mitotic DNA synthesis (MiDAS). After cell division, inherited DNA lesions are pr...
ORGANISM(S): Homo sapiens (Human) 
2026-08-26 | PXD069839 | Pride
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