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ProteomicsEXPLORING THE ANTI-INFLAMMATORY POTENTIAL OF THINNED APPLE POLYPHENOLS: MECHANISTIC PROTEOMICS INSIGHTS INTO DNBS-INDUCED COLITIS MODEL IN MICE
Ulcerative colitis (UC) is a multifactorial inflammatory bowel disease (IBD) with increasing incidence worldwide. Current treatments, such as NSAIDs and corticosteroids, provide partial symptom relief but are associated to significant side effects. This highlights the need for novel therapies with f...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD056914 | Pride
Nf-κb  nrf2  anti-inflammatory  anti-oxidant  polyphenols  proteomics  thinned apples 
ProteomicsThe Carnosine–HNE Michael Adduct as a Redox-Active Species Associated with Nrf2-Dependent Antioxidant and An-ti-Inflammatory Responses
Carnosine (CAR), an endogenous histidine-containing dipeptide, exhibits antioxidant and anti-inflammatory activity in various experimental models; however, its molecular mechanism of action remains poorly understood. Here, we demonstrate that the Michael adduct between CAR and 4-hydroxy-2-nonenal (H...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-06 | PXD075159 | Pride
Carnosine  4-hydroxy-2-nonenal (hne)  nrf2 activation  nf-κb  anti-inflammatory  anti-oxidant. 
ProteomicsAMOXICILLIN HAPTENATION OF α-ENOLASE
Allergic reactions to antibiotics are a major concern in the clinic, with almost 15% of the patients presenting with adverse reactions against β-lactam antibiotics. One of the mechanisms involved in this outcome is the modification of proteins by covalent binding of the drug (haptenation). Hence, th...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD029712 | Pride
Β-lactam antibiotics  protein modification by drugs  mass spectrometry  posttranslational modifications  acetylation  allergic responses to drugs 
ProteomicsEvaluation of the impact of the dietary inclusion of salty and sugary former food products on the liver and plasma profile of pigs through OMICS approaches
The research on alternative and sustainable feed ingredients is a challenge to reduce feed-food competition between humans and monogastrics, in particular pigs. Former food products (FFPs) drop out from the industrial production of food such as pasta, bread, snacks, and chips. They have a high nutri...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-10-17 | PXD049972 | Pride
Former food products Peptidomics Plasma Proteomics Pigs Liver 
ProteomicsProthrombin is a binding partner of the human Receptor of Advanced Glycation End products
The receptor for advanced glycation end products (RAGE) plays a key role in mammal physiology and in the etiology and progression of inflammatory and oxidative stress-based diseases. In adults, RAGE expression is high only in the lung where the protein concentrates in the basal membrane of Type I al...
ORGANISM(S): Homo sapiens (Human) 
2020-07-14 | PXD020355 | Pride
Receptor for advanced glycation end product (rage)  pattern recognition receptor (prr)  scavenger receptor  prothrombin  coagulation factor  mass spectrometry (ms)  plasma  protein -carboxylation  lung injury  protein-protein interaction. 
ProteomicsEpigenetic Modulation by Panobinostat primes Immune Readiness in Alveolar Macrophages
Epigenetic regulation through histone post-translational modifications (PTMs) enables macrophages to fine-tune gene expression and adapt to environmental cues. Alveolar macrophages (AMs), which reside in the lipid-rich lung microenvironment, must maintain lung homeostasis while preserving antimicrob...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-15 | PXD071228 | Pride
Quantitative proteomics  label-free quantification  panobinostat 
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