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TranscriptomicsLNCaP and C42B LSD1 knockdown microarray gene expression data and C42B androgen (DHT) stimulation microarray gene expression data
LSD1 (also known as KDM1A) is a histone demethylase and a key regulator of gene expression in embryonic stem cells and cancer. LSD1 was initially identified as a transcriptional repressor via its demethylation of active histone H3 marks (di-methyl lysine 4 [2MK4]). In prostate cancer, specifically, ...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-61630 | biostudies-arrayexpress
UnknownClinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study.
Purpose The prevalence and features of treatment-emergent small-cell neuroendocrine prostate cancer (t-SCNC) are not well characterized in the era of modern androgen receptor (AR)-targeting therapy. We sought to characterize the clinical and genomic features of t-SCNC in a multi-institutional prospe...
S-EPMC6366813 | biostudies-literature
UnknownLSD1 activates a lethal prostate cancer gene network independently of its demethylase function.
Medical castration that interferes with androgen receptor (AR) function is the principal treatment for advanced prostate cancer. However, clinical progression is universal, and tumors with AR-independent resistance mechanisms appear to be increasing in frequency. Consequently, there is an urgent nee...
S-EPMC5939079 | biostudies-literature
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