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TranscriptomicsSigma factor E of Mycobacterium tuberculosis controls the expression of bacterial components that modulate macrophages
Sigma factor E (SigE) controls the expression of genes that are essential for Mtb virulence. In this work, we have identified the SigE regulon during infection of macrophages Our results indicate that SigE regulates the expression of genes involved in the maintenance of Mtb cell envelope integrity a...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-25 | E-GEOD-7962 | biostudies-arrayexpress
UnknownA novel molecular diagnostics platform for somatic and germline precision oncology.
Not available
S-EPMC5511795 | biostudies-literature
TranscriptomicsWnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl
Although Bcr-Abl kinase inhibitors have proven effective in the treatment of chronic myeloid leukemia (CML), they generally fail to completely eradicate Bcr-Abl+ leukemia cells. To identify genes whose inhibition sensitizes Bcr-Abl+ leukemias to killing by Bcr-Abl inhibitors, we performed an RNAi-ba...
ORGANISM(S): Homo sapiens 
2010-07-15 | E-GEOD-21499 | biostudies-arrayexpress
UnknownComprehensive genomic diagnosis of non-syndromic and syndromic hereditary hearing loss in Spanish patients.
Not available
S-EPMC6038346 | biostudies-literature
UnknownTriarylpyridine Compounds and Chloroquine Act in Concert to Trigger Lysosomal Membrane Permeabilization and Cell Death in Cancer Cells.
Not available
S-EPMC7352983 | biostudies-literature
TranscriptomicsTranscription profiling of mouse ES cells, neural precursor cells and embryonic fibroblasts
Expression profiles for isogenic (129SvJae x C57BL/6) murine embryonic stem (ES) cells, neural precursors (NPC) obtained through in vitro differentiation of the ES cells, and embryonic fibroblasts (MEF) obtained at day 13.5. Experiment Overall Design: 3 replicates of wt ES cells, 3 replicates of wt...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-8024 | biostudies-arrayexpress
UnknownA randomized, placebo-controlled phase 2 study of paclitaxel in combination with reparixin compared to paclitaxel alone as front-line therapy for metastatic triple-negative breast cancer (fRida).
Not available
S-EPMC8558154 | biostudies-literature
UnknownmiR-155 in the progression of lung fibrosis in systemic sclerosis.
Not available
S-EPMC4932708 | biostudies-literature
UnknownPathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
Not available
S-EPMC4985612 | biostudies-literature
UnknownInterleukin-17 limits hypoxia-inducible factor 1α and development of hypoxic granulomas during tuberculosis.
Not available
S-EPMC5841875 | biostudies-literature
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