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ProteomicsEffects of lysine deacetylase inhibitor treatment on LPS responses of alveolar-like macrophages
Macrophages are key immune cells in tissues that are able to adapt their metabolic phenotype in response to different stimuli. Lysine deacetylases are important enzymes for regulating inflammatory gene expression and their inhibitors have anti-inflammatory effects in models of chronic obstructive pu...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-21 | PXD040933 | Pride
Dia proteomics Alveolar-like macrophages Lps activation Kdac inhibition Mouse 
GenomicsGeneration of Alveolar Assembloids (AlvAssemb) with Functional Alveolar-like Macrophages
Generation of Alveolar Assembloids (AlvAssemb) with Functional Alveolar-like Macrophages
PRJNA1123576 | ENA
TranscriptomicsImmunoproteasome dysfunction augments alternative polarization of alveolar macrophages
The proteasome is a central regulatory hub for intracellular signaling by degrading numerous signaling mediators. Immunoproteasomes are specialized types of proteasomes known to be involved in shaping adaptive immune responses, but their role for innate immune signaling is elusive. Here, we analyzed...
ORGANISM(S): Mus musculus 
2016-06-29 | E-GEOD-72000 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood monocyte (MONO), human peripheral blood monocyte derived macrophages treated with M-CSF (MACRO)and primary alveolar macrophages (BAL)
In order to study the gene expression profiles of monocyte and macrophages, we collected three type of cells and performed pair-wised comparison. It includes human peripheral blood monocyte (MONO), human peripheral blood monocyte derived macrophages treated with M-CSF (MACRO)and primary alveolar mac...
ORGANISM(S): Homo sapiens 
2006-12-01 | E-MEXP-524 | biostudies-arrayexpress
TranscriptomicsEffect of miR-182 on macrophage infection with Francisella tularensis
miR-182 over-expression enhances macrophage resistance to intracellular pathogens. This transcriptional profiling experiment was conducted to identify the basis for protection. Primary human alveolar macrophage-like monocyte derived macrophages were transfected with miR-182 mimic or control RNA, the...
ORGANISM(S): Homo sapiens 
2018-01-05 | E-MTAB-4551 | biostudies-arrayexpress
TranscriptomicsExpression data of influenza A-infected human type I-like alveolar epithelial cells
Pandemic influenza H1N1 (pdmH1N1) virus causes mild disease in humans but occasionally leads to severe complications and even death, especially in those who are pregnant or have underlying disease. Cytokine responses induced by pdmH1N1 viruses in vitro are comparable to other seasonal influenza viru...
ORGANISM(S): Homo sapiens 
2010-10-06 | E-GEOD-24533 | biostudies-arrayexpress
GenomicsmiRNA expression signatures in human alveolar macrophages after toll-like receptor activation
miRNA expression signatures in human alveolar macrophages after toll-like receptor activation
PRJNA509705 | ENA
TranscriptomicsHigh titers and low fucosylation of early anti-SARS-CoV-2 IgG promote hyper-inflammation by anti-inflammatory macrophages (MIL10)
Patients diagnosed with coronavirus disease 2019 (COVID-19) mostly become critically ill around the time of activation of the adaptive immune response. Here, we provide evidence that antibodies play a role in the worsening of disease at the time of seroconversion. We show that early phase severe acu...
ORGANISM(S): Homo sapiens 
2021-04-30 | E-MTAB-10431 | biostudies-arrayexpress
TranscriptomicsHigh salt primes a specific activation state of macrophages, M(Na)
Purpose: Investigate effects of high salt on human macrophage activation Methods: Human monocytes-derived macrophages were treated by additional 51mM NaCl for 24 hours (NaCl groups) or not (Control groups). mRNA profiles were generated by RNA-Seq, in triplicate, using Ion proton（Life tech). qRT–PCR ...
ORGANISM(S): Homo sapiens 
2015-09-23 | E-GEOD-68482 | biostudies-arrayexpress
UnknownGeneration of induced alveolar assembloids with functional alveolar-like macrophages.
Not available
S-EPMC11978882 | biostudies-literature
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