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TranscriptomicsM-OM-^CB-dependent yabJ-spoVG operon involved in regulation of extracellular nuclease, lipase and protease expression in Staphylococcus aureus
The alternative sigma factor M-OM-^CB of Staphylococcus aureus is involved in the coordination of the general stress response, expression of virulence determinants and modulation of antibiotic resistance levels. It controls a large regulon, either directly by recognizing conserved M-OM-^CB promoter ...
ORGANISM(S): Staphylococcus aureus 
2011-11-23 | E-GEOD-30115 | biostudies-arrayexpress
TranscriptomicsExon arrays from HeLa cells transfected with RBM4-specific siRNA
RBM4 is a RNA-binding protein (RBP) able to modulate splicing by promoting exon inclusion and shares an import pathway with other splicing factors in the nucleus. In earlier studies we found that RBM4 interacts and colocalizes with WT1, which has been implicated in 10M-bM-^@M-^S15% of WilmsM-bM-^@M-...
ORGANISM(S): Homo sapiens 
2012-07-14 | E-GEOD-32933 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of infiltrating glioma cells
Diffusely infiltrative growth of human astrocytic gliomas is one of the major obstacles to successful tumor therapy. Thorough insights into the miRNAs inolved in regulating glioma cell invasion thus appear of major relevance for the development of novel and advanced therapies. miRNA expression profi...
ORGANISM(S): Homo sapiens 
2012-05-03 | E-GEOD-37737 | biostudies-arrayexpress
TranscriptomicsHuman glioma cells: chronophin (CIN/PDXP) knockdown vs. control or rescue
Transcriptional profiling of human glioma cells to elucidate the role of chronophin (CIN/PDXP) for glioma pathogenesis three-condition experiment: control cells vs. knockdown and knockdown vs. rescue
ORGANISM(S): Homo sapiens 
2015-11-25 | E-GEOD-71786 | biostudies-arrayexpress
TranscriptomicsStudy of Cj1103 function in Campylobacter jejuni
In order to study the function of the Campylobacter jejuni Cj1103 gene, a series of experiments were carried out. Three strains were constructed: a Cj1103 knockout strain, a strain where the Cj1103 knockout was complemented in trans, and a strain with a second copy over-expressing Cj1103 from an met...
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 
2012-12-31 | E-GEOD-35121 | biostudies-arrayexpress
TranscriptomicsStudy of Cj0667 function in Campylobacter jejuni
In order to study the function of the Campylobacter jejuni Cj0667 gene, a series of experiments were carried out. Two strains were constructed: a Cj0667 knockout strain and a strain with a second copy over-expressing Cj0667 from an fdxA promoter. The transcriptomes of these were all compared to the ...
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 
2012-12-31 | E-GEOD-35120 | biostudies-arrayexpress
TranscriptomicsStudy of Cj0138 function in Campylobacter jejuni
In order to study the function of the Campylobacter jejuni Cj0138 gene, a series of experiments were carried out. Three strains were constructed: a Cj0138 knockout strain, a strain where the Cj0138 knockout was complemented in trans, and a strain with a second copy over-expressing Cj0138 from an fdx...
ORGANISM(S): Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 
2012-12-31 | E-GEOD-35119 | biostudies-arrayexpress
TranscriptomicsHuman glioma cells treated with irradiation and/or CCI-779
Gene expression profiling of human glioma cell line LN-308. Cells were treated with the mTOR inhibitor CCI-779 or irradiated with a single dose of 4 Gy or a combination of both. The objective of this studywas to evaluate CCI-779 as a radio-sensitizing agent and to elucidate the underlying mechanisms...
ORGANISM(S): Homo sapiens 
2011-09-19 | E-GEOD-24232 | biostudies-arrayexpress
TranscriptomicsWapl controls higher-order chromatin structure in interphase chromosomes (gene expression)
Mammalian genomes contain several billion base pairs of DNA which are packaged in chromatin fibers. At selected gene loci, cohesin complexes have been proposed to arrange chromatin fibers into higher-order structures, but it is poorly understood how cohesin performs this task, how important this fun...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-41460 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of 6 acute hepatitis C patients
Approximately 50% of patients with chronic hepatitis C (CHC) have a sustained virologic response (SVR) to treatment with pegylated interferon (pegINF)-M-NM-1 and ribavirin. Non-response to treatment is associated with constitutively increased expression of IFN-stimulated genes (ISGs) in the liver. T...
ORGANISM(S): Homo sapiens 
2012-06-08 | E-GEOD-38597 | biostudies-arrayexpress
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