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TranscriptomicsPin1 is required for sustained B cell proliferation upon oncogenic activation of Myc
The c-myc proto-oncogene is activated by translocation in Burkitt's lymphoma and substitutions in codon 58 stabilize the Myc protein or augment its oncogenic potential. In wild-type Myc, phosphorylation of Ser 62 and Thr 58 provide a landing pad for the peptidyl prolyl-isomerase Pin1, which in turn ...
ORGANISM(S): Mus musculus 
2016-06-14 | E-GEOD-77482 | biostudies-arrayexpress
TranscriptomicsRegulation of the core pre-mRNA splicing machinery by MYC and PRMT5 is essential to sustain lymphomagenesis [B-cells]
Over-expressed MYC binds to virtually all active promoters within a cell, although with different binding affinities, and modulates gene expression, both positively and negatively. Here, we show that during lymphomagenesis in Eµ-myc transgenic mice, MYC directly up-regulates the transcription of the...
ORGANISM(S): Mus musculus 
2015-05-19 | E-GEOD-60188 | biostudies-arrayexpress
TranscriptomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [RNA-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-51008 | biostudies-arrayexpress
GenomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [ChIP-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-51004 | biostudies-arrayexpress
Unknownp53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo: Computational analysis of next-generation sequencing data.
Not available
S-EPMC4778592 | biostudies-literature
UnknownGenome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo.
Not available
S-EPMC4694782 | biostudies-literature
UnknownAn early Myc-dependent transcriptional program orchestrates cell growth during B-cell activation.
Not available
S-EPMC6726900 | biostudies-literature
GenomicsSelective transcriptional regulation by Myc in cellular growth control and lymphomagenesis [DNAse-Seq]
The c-myc proto-oncogene product, Myc, is a transcription factor that binds thousands of genomic loci. Recent work suggested that rather than up- and down-regulating selected groups of genes, Myc targets all active promoters and enhancers in the genome (a phenomenon termed "invasion") and ...
ORGANISM(S): Mus musculus 
2014-07-07 | E-GEOD-50823 | biostudies-arrayexpress
UnknownPin1 is required for sustained B cell proliferation upon oncogenic activation of Myc.
Not available
S-EPMC5008323 | biostudies-literature
UnknownTargeting mitochondrial respiration and the BCL2 family in high-grade MYC-associated B-cell lymphoma.
Not available
S-EPMC8895457 | biostudies-literature
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