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TranscriptomicsAssessment of low-dose BPA toxicity in thyroid follicular cells by gene expression microarray.
Gene expression microarrays were performed to investigate the molecular effects of exposure to BPA on thyrocytes (FRTL-5). Cells were treated with low-lose BPA (10^-9 M) at different time points to analyse time dependent toxicity.
ORGANISM(S): Rattus norvegicus 
2016-02-29 | E-MTAB-4458 | biostudies-arrayexpress
TranscriptomicsRNA-seq of immortalized rat thyrocytes (PCCl3) treated with two thyroid disrupting chemicals (ethylenethiourea and chlorpyrifos) against untreated controls
The transcriptomic dose-dependent response of rat immortalized thyrocytes to two thyroid disrupting chemicals was investigated by RNA-seq experiment. PCCl3 cells were exposed for one week to different doses of ethylenethiourea (ETU) and chlorpyrifos (CPF) and to their combinations.
ORGANISM(S): Rattus norvegicus 
2016-12-06 | E-MTAB-5269 | biostudies-arrayexpress
TranscriptomicsGene expression profile in a breast cancer cell line upon hormonal treatments
MCF-7 TET Off cells (MCF-7 wt) were used to produce stable clones expressing ER-alpha tagged with TAP-tag at the C-term (C-TAP-ER-alpha). All cells were grown in Dulbecco's modified Eagle's medium (DMEM), starved by using DMEM w/o phenol red and 5% Dextran Coated Charcoal stripped serum (DCC-FBS) fo...
ORGANISM(S): Homo sapiens 
2012-06-25 | E-MTAB-1196 | biostudies-arrayexpress
TranscriptomicsToxicogenomic analysis in liver of mice exposed to polluted groundwater
Gene expression microarrays were performed to investigate the molecular effects of exposure to environmental polluted groundwater. Mice were treated with polluted waters collected from dumps located upstream and downstream a sanitary landfills. Gene expression profiling of mouse liver was analyzed ...
ORGANISM(S): Mus musculus 
2014-09-30 | E-MTAB-2905 | biostudies-arrayexpress
TranscriptomicsToxicogenomic analysis in liver of zebrafish exposed to polluted groundwater
Gene expression microarrays were performed to investigate the molecular effects of exposure to environmental polluted groundwater. Zebrafish was treated with polluted waters collected from dumps located upstream and downstream a sanitary landfills. Gene expression profiling of zebrafish liver was a...
ORGANISM(S): Danio rerio 
2014-09-30 | E-MTAB-2906 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling by array of ovaries from aged mice
We transcriptionally profiled ovaries harvested from young and middle-aged outbred CD1 mice to elucidate mechanisms and identify novel markers of ovarian aging.
ORGANISM(S): Mus musculus 
2018-12-15 | E-MTAB-7493 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profile between ER-beta- and ER-beta+ breast tumors.
FFPE tissues samples were cut in 5-µm-thick sections on a microtome with a disposable blade. RNA was extracted either from three or eight sequential sections using miRNeasy FFPE Kit (QIAGEN), following the steps described in the manufacturers protocol. RNA extracted from same biological samples and...
ORGANISM(S): Homo sapiens 
2011-10-14 | E-TABM-1054 | biostudies-arrayexpress
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