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TranscriptomicsTranscription profiling of rat wild-type and (6) MRP2 deficient kidneys that had been transplanted in wild-type recipients reveals kidney-specific dysfunction of the organic anion transporter mrp2 (ABCC2): functional consequences for renal grafts
Transplanting renal allografts represents the major curative treatment of chronic renal failure. Despite recent advances in immunosuppressive therapy, long-term survival of allografts remains a major clinical problem. Kidney function depends in part on transport proteins such as MRP2 (ABCC2) which f...
ORGANISM(S): Rattus norvegicus 
2009-09-04 | E-GEOD-10949 | biostudies-arrayexpress
TranscriptomicsRac1-Induced Connective Tissue Growth Factor regulates Connexin 43 and N-Cadherin Expression in Atrial Fibrillation
Objectives: We studied the signal transduction of atrial structural remodelling that contributes to the pathogenesis of atrial fibrillation (AF). Backround: Fibrosis is a hallmark of arrhythmogenic structural remodelling but the underlying molecular mechanisms are incompletely understood. Methods: W...
ORGANISM(S): Homo sapiens 
2010-02-21 | E-GEOD-14975 | biostudies-arrayexpress
TranscriptomicsRegulation of interferon-inducible proteins by doxorubicin via IFN-alpha-JAK-STAT signaling in tumor cells
Activation of the immune system is a way for host tissue to defend itself against tumor growth. Hence, treatment strategies that are based on immunomodulation are on the rise. Conventional cytostatic drugs such as the anthracycline doxorubicin can also activate immune cell functions of macrophages a...
ORGANISM(S): Homo sapiens 
2012-05-22 | E-GEOD-30988 | biostudies-arrayexpress
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