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MetabolomicsMetabolomic analysis on Microcystis aeruginosa cells under various amino acid supplementation conditions
Threonine, an essential amino acid for translation, exhibits toxicity towards slow-growing cyanobacteria. This prompted us to perform transcriptomic and proteomic analyses using Microcystis aeruginosa cells treated with threonine, revealing a noteworthy upregulation of thrC, annotated as pyridoxal 5...
2025-04-02 | MTBLS11852 | MetaboLights
MetabolomicsMultiomic profiling of medulloblastoma reveals subtype-specific targetable alterations at the proteome and N-glycan level (Amino acid profiling)

Medulloblastomas (MBs) are malignant pediatric brain tumors that are molecularly and clinically very heterogenous. The application of omics technologies - mainly studying nucleic acids - has significantly improved MB classification and stratification, but treatment options are still unsatisfactor...

2024-05-30 | MTBLS9836 | MetaboLights
MetabolomicsProfiling aromatic amino acid metabolome in the human gut microbiota reveals Clostridioides difficile specific N-acyl amino acids

Owing to its compositional and chemical complexity, much of the gut microbiota metabolome remains poorly characterized. Aromatic amino acids (AAAs) have a history of being privileged substrates for the biosynthesis of diverse bioactive metabolites and thus represent a potentially rich source of b...

2026-07-23 | MTBLS13404 | MetaboLights
MetabolomicsAlterations in the amino acid profile in patients with papillary thyroid carcinoma with and without Hashimoto’s thyroiditis

PURPOSE: Amino acids (AAs) play important physiological roles in living cells. Some amino acid changes in blood are specific for autoimmune disorders, and some are specific for thyroid cancer. The aims of this study were to profile AA metabolites in the serum of patients with pap...

2023-08-09 | MTBLS8012 | MetaboLights
MetabolomicsChanges in Amino Acid and Acylcarnitine Plasma Profiles for Distinguishing Patients with Multiple Sclerosis from Healthy Controls
McDonald criteria and magnetic resonance imaging (MRI) are used for the diagnosis of multiple sclerosis (MS); nevertheless, it takes a considerable amount of time to make a clinical decision. Amino acid and fatty acid metabolic pathways are disturbed in MS, and this information could be useful for d...
2022-05-24 | MTBLS704 | MetaboLights
MetabolomicsSkeletal muscle metabolomics and blood biochemistry analysis reveal metabolic changes associated with dietary amino acid supplementation in dairy calves
The effects of different amino acid (AA) supplementations of milk protein-based milk replacers in pre-ruminant calves from 3 days to 7 weeks of age were studied. Animals were divided into 4 groups: Ctrl) Control group fed with milk protein-based milk replacer without supplementation; GP) supplementa...
2018-10-08 | MTBLS720 | MetaboLights
MetabolomicsIntegrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection
The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Quantitative mea...
2021-01-29 | MTBLS2014 | MetaboLights
MetabolomicsLarge neutral amino acid levels tune perinatal neuronal excitability and survival
Surprisingly little is known about the critical metabolic changes that neural cells have to undergo during development and how even mild, temporary shifts in this program can influence brain circuitries and behavior. Inspired by the discovery that mutations in SLC7A5, a transporter of metabolically-...
2023-03-28 | MTBLS6578 | MetaboLights
MetabolomicsSarcopenic metabolomic profile reflected a sarcopenic phenotype associated with amino acid and essential fatty acid changes

INTRODUCTION: Although sarcopenia greatly affects health and quality of life in older people, its pathophysiological causes are not fully elucidated. To face this challenge, omics technologies can be used. The metabolome gives a vision of the interaction between the genome and t...

2021-09-29 | MTBLS2679 | MetaboLights
MetabolomicsAn explainable prognostic prediction panel for sepsis based on serum amino acid profiles

Sepsis is a life-threatening syndrome requiring aggressive management, and novel noninvasive biomarkers to enable risk stratification of sepsis with high confidence and to predict the sepsis-related outcomes are urgently needed. 

A mass spectrometry–based quantitative method was used t...

2026-05-24 | MTBLS14567 | MetaboLights
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